Notch4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Notch4
notch 4
MGI:107471

40 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Notch4^{tm1(KOMP)Vlcg}/Notch4⁺ involves: C57BL/6NTac	abnormal retina blood vessel morphology	J:212472
Notch4^{tm1(KOMP)Vlcg}/Notch4⁺ involves: C57BL/6NTac	abnormal retina vasculature morphology	J:212472
Notch4^{tm1(KOMP)Vlcg}/Notch4^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	abnormal retina vasculature morphology	J:212472
	normal mortality/aging	J:212472
Notch4^{tm1.1(cre/ERT2)Sat}/Notch4⁺ C57BL/6-Notch4^{tm1.1(cre/ERT2)Sat}	no abnormal phenotype detected	J:179632
Notch4^tm1Grid/Notch4⁺ involves: 129S1/Sv * C57BL/6J	abnormal retina blood vessel morphology	J:212472
Notch4^tm1Grid/Notch4⁺ involves: 129S1/Sv * C57BL/6J	abnormal retina vasculature morphology	J:212472
Notch4^tm1Grid/Notch4^tm1Grid involves: 129S1/Sv	no abnormal phenotype detected	J:62571
Notch4^tm1Grid/Notch4^tm1Grid involves: 129S1/Sv * C57BL/6J	abnormal retina blood vessel morphology	J:212472
Notch4^tm1Grid/Notch4^tm1Grid involves: 129S1/Sv * C57BL/6J	abnormal retina vasculature morphology	J:212472
Tg(MMTV-Notch4)3Rnc/0 involves: FVB/N	abnormal epididymis epithelium morphology	J:11644
	abnormal gland morphology	J:11644
	abnormal mammary gland development	J:11644
	abnormal mammary gland morphology	J:11644
	abnormal nasolacrimal duct morphology	J:11644
	abnormal parotid gland morphology	J:11644
	abnormal salivary gland duct morphology	J:11644
	abnormal sublingual gland morphology	J:11644
	enlarged epididymis	J:11644
	Harderian gland hyperplasia	J:11644
	increased mammary adenocarcinoma incidence	J:11644
	increased metastatic potential	J:11644
	increased salivary adenocarcinoma incidence	J:11644
	lactation failure	J:11644
	male infertility	J:11644
	mammary gland duct hyperplasia	J:11644
	oligozoospermia	J:11644
	submandibular gland hyperplasia	J:11644
Tg(Tek-tTA)1Rwng/0 Tg(tetO-Notch4*)1Rwng/0 involves: FVB/N	abnormal blood vessel physiology	J:139943
	abnormal brain vasculature morphology	J:139943
	abnormal cerebellum morphology	J:139943
	abnormal midbrain morphology	J:139943
	abnormal middle cerebral artery morphology	J:139943
	abnormal neocortex morphology	J:139943
	abnormal nervous system physiology	J:139943
	abnormal thrombosis	J:139943
	arteriovenous malformation	J:139943
	ataxia	J:139943
	calcified brain	J:139943
	cerebellum hemorrhage	J:139943
	cerebral arteriovenous malformation	J:139943
	hemorrhage	J:139943
	increased neuron apoptosis	J:139943
	intraventricular hemorrhage	J:139943
	premature death	J:139943
	seizures	J:139943

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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