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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch4
notch 4
MGI:107471
40 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Notch4tm1(KOMP)Vlcg/Notch4+
involves: C57BL/6NTac 		abnormal retina blood vessel morphology J:212472
abnormal retina vasculature morphology J:212472
Notch4tm1(KOMP)Vlcg/Notch4tm1(KOMP)Vlcg
involves: C57BL/6NTac 		abnormal retina vasculature morphology J:212472
normal mortality/aging J:212472
Notch4tm1.1(cre/ERT2)Sat/Notch4+
C57BL/6-Notch4tm1.1(cre/ERT2)Sat 		no abnormal phenotype detected J:179632
Notch4tm1Grid/Notch4+
involves: 129S1/Sv * C57BL/6J 		abnormal retina blood vessel morphology J:212472
abnormal retina vasculature morphology J:212472
Notch4tm1Grid/Notch4tm1Grid
involves: 129S1/Sv 		no abnormal phenotype detected J:62571
Notch4tm1Grid/Notch4tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal retina blood vessel morphology J:212472
abnormal retina vasculature morphology J:212472
Tg(MMTV-Notch4)3Rnc/0
involves: FVB/N 		abnormal epididymis epithelium morphology J:11644
abnormal gland morphology J:11644
abnormal mammary gland development J:11644
abnormal mammary gland morphology J:11644
abnormal nasolacrimal duct morphology J:11644
abnormal parotid gland morphology J:11644
abnormal salivary gland duct morphology J:11644
abnormal sublingual gland morphology J:11644
enlarged epididymis J:11644
Harderian gland hyperplasia J:11644
increased mammary adenocarcinoma incidence J:11644
increased metastatic potential J:11644
increased salivary adenocarcinoma incidence J:11644
lactation failure J:11644
male infertility J:11644
mammary gland duct hyperplasia J:11644
oligozoospermia J:11644
submandibular gland hyperplasia J:11644
Tg(Tek-tTA)1Rwng/0
Tg(tetO-Notch4*)1Rwng/0
involves: FVB/N 		abnormal blood vessel physiology J:139943
abnormal brain vasculature morphology J:139943
abnormal cerebellum morphology J:139943
abnormal midbrain morphology J:139943
abnormal middle cerebral artery morphology J:139943
abnormal neocortex morphology J:139943
abnormal nervous system physiology J:139943
abnormal thrombosis J:139943
arteriovenous malformation J:139943
ataxia J:139943
calcified brain J:139943
cerebellum hemorrhage J:139943
cerebral arteriovenous malformation J:139943
hemorrhage J:139943
increased neuron apoptosis J:139943
intraventricular hemorrhage J:139943
premature death J:139943
seizures J:139943
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory