Cd38 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd38
CD38 antigen
MGI:107474

26 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd38^{em1(IMPC)Ccpcz}/Cd38^{em1(IMPC)Ccpcz} C57BL/6NCrl-Cd38^{em1(IMPC)Ccpcz}/Ccpcz	abnormal digit morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased CD4-positive NK T cell number	J:211773
	decreased CD4-positive, alpha-beta T cell number	J:211773
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:211773
	decreased effector memory T-helper cell number	J:211773
	decreased memory-marker CD4-positive NK T cell number	J:211773
	decreased NK T cell number	J:211773
	decreased T-helper cell number	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	increased effector memory CD8-positive, alpha-beta T cell number	J:211773
	increased NK cell number	J:211773
Cd38^tm1Lnd/Cd38^tm1Lnd B6.129P2-Cd38^tm1Lnd	decreased pancreatic beta cell mass	J:116576
	disorganized pancreatic islets	J:116576
	normal homeostasis/metabolism phenotype	J:116576
	increased pancreatic islet cell apoptosis	J:116576
	insulin resistance	J:116576
Cd38^tm1Lnd/Cd38^tm1Lnd involves: 129P2/OlaHsd * C57BL/6J	abnormal enzyme/coenzyme activity	J:49170
Cd38^tm1Lnd/Cd38^tm1Lnd involves: 129P2/OlaHsd * C57BL/6J	abnormal humoral immune response	J:49170
Cd38^tm1Lnd/Cd38^tm1Lnd NOD.129P2(B6)-Cd38^tm1Lnd/LtJ	increased susceptibility to autoimmune diabetes	J:108097
	increased T cell apoptosis	J:108097
	insulitis	J:108097
Cd38^tm1Okam/Cd38^tm1Okam involves: C57BL/6 * CBA	decreased circulating insulin level	J:52933
Cd38^tm1Okam/Cd38^tm1Okam involves: C57BL/6 * CBA	impaired glucose tolerance	J:52933

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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