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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stim1
stromal interaction molecule 1
MGI:107476
129 phenotypes from 10 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Stim1em1(IMPC)Mbp/Stim1+
C57BL/6N-Stim1em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal lymph node morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
decreased exploration in new environment J:211773
embryonic growth retardation J:211773
enlarged kidney J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased neutrophil cell number J:211773
microphthalmia J:211773
small kidney J:211773
Stim1em1(IMPC)Mbp/Stim1em1(IMPC)Mbp
C57BL/6N-Stim1em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
microphthalmia J:211773
preweaning lethality, complete penetrance J:211773
Stim1Gt(GST050)Byg/Stim1Gt(GST050)Byg
involves: 129P2/OlaHsd 		abnormal cell physiology J:178553
Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
involves: 129P2/OlaHsd 		abnormal neuron physiology J:159604
Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal calcium ion homeostasis J:137364
abnormal platelet activation J:137364
abnormal thrombosis J:137364
normal cardiovascular system phenotype J:137364
cyanosis J:137364
decreased platelet aggregation J:137364
normal hematopoietic system phenotype J:137364
normal homeostasis/metabolism phenotype J:137364
neonatal lethality, incomplete penetrance J:137364
postnatal growth retardation J:137364
Stim1Sax/Stim1+
involves: C3HeB/FeJ * C57BL/6 		abnormal bone marrow morphology J:127381
abnormal platelet activation J:127381
abnormal thrombopoiesis J:127381
abnormal thrombosis J:127381
enlarged spleen J:127381
normal immune system phenotype J:127381
increased bleeding time J:127381
increased megakaryocyte cell number J:127381
increased spleen red pulp amount J:127381
myelofibrosis J:127381
thrombocytopenia J:127381
Stim1Sax/Stim1Sax
involves: C3HeB/FeJ * C57BL/6 		embryonic lethality between somite formation and embryo turning, incomplete penetrance J:127381
hemorrhage J:127381
lethality throughout fetal growth and development, complete penetrance J:127381
Stim1tm1.1Kuro/Stim1+
C57BL/6-Stim1tm1.1Kuro 		decreased susceptibility to type I hypersensitivity reaction J:130477
Stim1tm1.1Kuro/Stim1tm1.1Kuro
C57BL/6-Stim1tm1.1Kuro 		abnormal cytokine secretion J:130477
abnormal interleukin secretion J:130477
decreased birth body size J:130477
decreased interleukin-6 secretion J:130477
decreased interleukin-13 secretion J:130477
decreased mast cell degranulation J:130477
decreased tumor necrosis factor secretion J:130477
perinatal lethality, complete penetrance J:130477
respiratory failure J:130477
Stim1tm1.1Pg/Stim1+
involves: C57BL/6 		abnormal circulating creatine kinase level J:285187
abnormal muscle physiology J:285187
abnormal skeletal muscle fiber morphology J:285187
abnormal skeletal muscle morphology J:285187
abnormal spine curvature J:285187
centrally nucleated skeletal muscle fibers J:285187
decreased body size J:285187
decreased body weight J:285187
decreased gastrocnemius weight J:285187
decreased grip strength J:285187
decreased Ly6C low monocyte number J:285187
decreased NK cell number J:285187
decreased quadriceps weight J:285187
decreased skeletal muscle fiber diameter J:285187
decreased skeletal muscle weight J:285187
enlarged heart J:285187
enlarged spleen J:285187
impaired coordination J:285187
increased bleeding time J:285187
increased Ly6C high monocyte number J:285187
increased soleus weight J:285187
increased variability of skeletal muscle fiber size J:285187
myopathy J:285187
skeletal muscle endomysial fibrosis J:285187
skeletal muscle necrosis J:285187
thrombocytopenia J:285187
tremors J:285187
Stim1tm1.1Rao/Stim1tm1.1Rao
involves: BALB/cJ * C57BL/6 * ICR * SJL 		perinatal lethality, incomplete penetrance J:133262
postnatal growth retardation J:133262
postnatal lethality, complete penetrance J:133262
Stim1tm1.1Rao/Stim1tm1.1Rao
involves: BALB/cJ * C57BL/6 * SJL 		abnormal cell physiology J:133262
perinatal lethality, incomplete penetrance J:133262
postnatal lethality, complete penetrance J:133262
Stim1tm1Kuro/Stim1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 		abnormal B cell calcium ion homeostasis J:172608
decreased B cell proliferation J:172608
decreased interleukin-10 secretion J:172608
Stim1tm1Rao/Stim1tm1Rao
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 * SJL 		abnormal CD4-positive, alpha-beta T cell physiology J:133262
decreased interleukin-2 secretion J:133262
increased lymphocyte cell number J:133262
Stim1tm3Ics/Stim1+
involves: C57BL/6N 		abnormal bone structure J:277842
abnormal megakaryocyte morphology J:277842
abnormal muscle physiology J:277842, J:327797
abnormal muscle weight J:277842
abnormal oxidative phosphorylation J:327797
abnormal skeletal muscle fiber mitochondrial morphology J:277842
abnormal skeletal muscle fiber morphology J:277842, J:327797
abnormal skeletal muscle morphology J:277842
normal behavior/neurological phenotype J:277842
centrally nucleated skeletal muscle fibers J:277842
decreased alkaline phosphatase activity J:277842
decreased body fat mass J:277842
decreased body length J:277842
decreased body weight J:277842
decreased bone stiffness J:277842
decreased bone strength J:277842
decreased bone trabecula number J:277842
decreased circulating calcium level J:277842
decreased circulating glucose level J:277842
decreased gastrocnemius weight J:277842
decreased grip strength J:277842
decreased internal diameter of femur J:277842
decreased internal diameter of tibia J:277842
decreased lean body mass J:277842
decreased locomotor activity J:277842
decreased lymphocyte cell number J:277842
decreased mitochondrial number J:327797
decreased muscle fatigability J:277842
decreased NK T cell number J:277842
decreased regulatory T cell number J:277842
decreased subcutaneous adipose tissue amount J:277842
enhanced skeletal muscle regeneration J:327797
impaired muscle relaxation J:277842
improved glucose tolerance J:277842
increased bleeding time J:277842
increased circulating alanine transaminase level J:277842
increased circulating aspartate transaminase level J:277842
increased circulating creatine kinase level J:277842
increased circulating insulin level J:277842
increased circulating phosphate level J:277842
increased endoplasmic reticulum stress J:327797
increased mean platelet volume J:277842
increased monocyte cell number J:277842
increased neutrophil cell number J:277842
increased skeletal muscle cell apoptosis J:327797
increased soleus weight J:277842
increased spleen weight J:277842
lethality throughout fetal growth and development, incomplete penetrance J:277842
muscle weakness J:277842
myositis J:277842
paresis J:277842
perinatal lethality, incomplete penetrance J:277842
premature death J:277842
skeletal muscle fibrosis J:277842
thick dermal layer J:277842
thrombocytopenia J:277842
Stim1tm3Ics/Stim1tm3Ics
involves: C57BL/6N 		lethality throughout fetal growth and development, complete penetrance J:277842
perinatal lethality, complete penetrance J:277842
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory