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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501
75 phenotypes from 7 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0
involves: C57BL/6 * CBA/J 		abnormal circulating glucagon level J:146650
abnormal circulating glucose level J:146650
abnormal pancreas morphology J:146650
abnormal pancreatic alpha cell morphology J:146650
abnormal pancreatic beta cell physiology J:146650
abnormal pancreatic islet morphology J:146650
decreased circulating glucagon level J:146650
decreased circulating insulin level J:146650
decreased insulin secretion J:146650
decreased pancreas weight J:146650
decreased pancreatic alpha cell number J:146650
decreased pancreatic beta cell number J:146650
decreased pancreatic islet number J:146650
hyperglycemia J:146650
increased circulating glucagon level J:146650
slow postnatal weight gain J:146650
small pancreatic islets J:146650
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal action potential J:162008
abnormal channel response J:162008
abnormal nervous system electrophysiology J:162008
decreased body weight J:162008
decreased grip strength J:162008
hyperactivity J:162008
impaired balance J:162008
impaired coordination J:162008
muscle weakness J:162008
perinatal lethality, incomplete penetrance J:162008
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6 		abnormal pancreatic alpha cell morphology J:144715
abnormal pancreatic beta cell morphology J:144715
abnormal pancreatic beta cell physiology J:144715
abnormal pancreatic islet morphology J:144715
decreased body weight J:144715
decreased circulating insulin level J:144715
decreased insulin secretion J:144715
decreased pancreatic beta cell number J:144715
increased circulating glucagon level J:144715
increased circulating glucose level J:144715
increased pancreatic alpha cell number J:144715
polyuria J:144715
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)#Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA 		hyperglycemia J:210493
Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H 		abnormal ear morphology J:211773
decreased fasting circulating glucose level J:211773
decreased hemoglobin content J:211773
impaired glucose tolerance J:211773
Kcnj11tm1Sse/Kcnj11+
Tg(Ins1-Kcnj11*)#Nich/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal pancreatic beta cell physiology J:94610
decreased insulin secretion J:94610
impaired glucose tolerance J:94610
improved glucose tolerance J:94610
increased circulating glucose level J:94610
increased circulating insulin level J:94610
increased insulin secretion J:94610
Kcnj11tm1Sse/Kcnj11tm1Sse
B6.129P2-Kcnj11tm1Sse 		abnormal action potential J:106396
abnormal food intake J:69163, J:157001
abnormal glucose homeostasis J:69163
abnormal locomotor activation J:157001
abnormal nerve fiber response J:69163
decreased abdominal fat pad weight J:157001
decreased aerobic running capacity J:157001
decreased glucagon secretion J:69163
decreased subcutaneous adipose tissue amount J:157001
decreased susceptibility to diet-induced obesity J:157001
hypoglycemia J:69163
increased circulating atrial natriuretic factor J:106396
increased energy expenditure J:157001
increased mean systemic arterial blood pressure J:106396
increased oxygen consumption J:157001
normal pigmentation phenotype J:157001
slow postnatal weight gain J:157001
Kcnj11tm1Sse/Kcnj11tm1Sse
involves: 129P2/OlaHsd 		abnormal muscle relaxation J:105244
abnormal nerve fiber response J:69832
abnormal nerve fiber response intensity J:69832
convulsive seizures J:69832
decreased circulating insulin level J:49755
impaired glucose tolerance J:49755
impaired skeletal muscle contractility J:105244, J:140833
increased insulin sensitivity J:49755
increased muscle fatigability J:140833
increased susceptibility to induced morbidity/mortality J:69832
myoclonus J:69832
tonic-clonic seizures J:69832
Kcnj11tm1Sse/Kcnj11tm1Sse
involves: 129P2/OlaHsd * C57BL/6 		abnormal emotion/affect behavior J:112822
abnormal locomotor activation J:112822
abnormal motor capabilities/coordination/movement J:112822
abnormal spatial reference memory J:112822
decreased anxiety-related response J:112822
decreased exploration in new environment J:112822
decreased vertical activity J:112822
impaired coordination J:112822
increased anxiety-related response J:112822
Kcnj11tm1Sse/Kcnj11tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased insulin secretion J:94610
normal homeostasis/metabolism phenotype J:94610
impaired glucose tolerance J:94610
increased circulating glucose level J:94610
Kcnj11Y12stop/Kcnj11Y12stop
involves: BALB/c * C3H/HeH 		decreased glucagon secretion J:122088
increased insulin secretion J:122088
Tg(Ins1-Kcnj11*)#Nich/?
B6.Cg-Tg(Ins1-Kcnj11*)#Nich 		increased insulin secretion J:94610
Tg(Myh6-Kcnj11*)1Wco/0
involves: C57BL/6 * FVB/N 		abnormal impulse conducting system conduction J:116284
abnormal myocardial fiber currents J:116284
abnormal myocardial fiber physiology J:116284
decreased QRS amplitude J:116284
premature death J:116284
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory