Cln3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cln3
CLN3 lysosomal/endosomal transmembrane protein, battenin
MGI:107537

49 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cln3^em1Dprc/Cln3^em1Dprc C57BL/6-Cln3^em1Dprc	abnormal astrocyte morphology	J:294634
	abnormal enzyme/coenzyme activity	J:294634
	abnormal lysosome morphology	J:294634
	astrocytosis	J:294634
	decreased body weight	J:294634
	impaired coordination	J:294634
	increased microglial cell activation	J:294634
Cln3^tm1.1Mem/Cln3^tm1.1Mem involves: 129S/SvEv * CD-1	abnormal cerebellar Purkinje cell layer	J:79615
	abnormal dentate gyrus morphology	J:79615
	abnormal gait	J:79615
	abnormal hepatocyte morphology	J:79615
	abnormal hippocampus pyramidal cell morphology	J:79615
	abnormal nervous system morphology	J:79615
	abnormal postnatal subventricular zone morphology	J:79615
	abnormal retina ganglion cell morphology	J:79615
	abnormal retina neuronal layer morphology	J:79615
	normal behavior/neurological phenotype	J:79615
	decreased retina photoreceptor cell number	J:79615
	gliosis	J:79615
	limb grasping	J:79615
	premature death	J:79615
	retina degeneration	J:79615
	short stride length	J:79615
Cln3^tm1Blda/Cln3^tm1Blda B6.129-Cln3^tm1Blda	abnormal brain morphology	J:125194
	abnormal kidney morphology	J:160849
	abnormal locomotor activation	J:125194
	abnormal lysosome morphology	J:125194
	decreased urine osmolality	J:160849
	decreased urine potassium level	J:160849
	impaired coordination	J:125194
	increased blood osmolality	J:160849
	increased circulating potassium level	J:160849
	increased susceptibility to pharmacologically induced seizures	J:125194
	limb grasping	J:125194
	polydipsia	J:160849
	polyuria	J:160849
	normal renal/urinary system phenotype	J:160849
	tremors	J:125194
Cln3^tm1Mkat/Cln3^tm1Mkat involves: 129X1/SvJ * C57BL/6J	abnormal cerebral cortex morphology	J:57155
	abnormal fertility/fecundity	J:57155
	abnormal liver morphology	J:57155
	abnormal lysosome morphology	J:57155
Cln3^tm1Nbm/Cln3^tm1Nbm 129S6/SvEvTac-Cln3^tm1Nbm	abnormal retina ganglion layer morphology	J:109790
	abnormal retina inner nuclear layer morphology	J:109790
	abnormal retina morphology	J:109790
Cln3^tm1Nbm/Cln3^tm1Nbm involves: 129S6/SvEvTac * C57BL/6J	abnormal cell adhesion	J:233445
	abnormal dendritic cell physiology	J:233445
	abnormal macrophage physiology	J:233445
	abnormal professional antigen presenting cell morphology	J:233445
	decreased macrophage cytokine production	J:233445
Cln3^tm1Nbm/Cln3^tm1Nbm involves: 129S6/SvEvTac * NIH Black Swiss	abnormal basal ganglion morphology	J:58230
	abnormal brain morphology	J:58230
	abnormal brainstem morphology	J:58230
	abnormal cerebral cortex morphology	J:58230
	abnormal hippocampus morphology	J:58230
	abnormal lysosome morphology	J:58230

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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