Sox17 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sox17
SRY (sex determining region Y)-box 17
MGI:107543

68 phenotypes from 8 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox17^SHIVA/Sox17⁺ either: C57BL/6-Sox17^SHIVA or (involves: C57BL/6 * C3H/HeN)	abnormal enzyme/coenzyme level	J:219119
	abnormal lipid metabolism	J:219119
	abnormal metabolism	J:219119
	abnormal peroxisome morphology	J:219119
	decreased birth body size	J:219119
	decreased circulating HDL cholesterol level	J:219119
	decreased circulating ketone body level	J:219119
	decreased fasting circulating glucose level	J:219119
	decreased liver triglyceride level	J:219119
	ovary atrophy	J:219119
	reduced female fertility	J:219119
Sox17^tm1.1Nat/Sox17^tm1.1Nat involves: 129 * C57BL/6 * SJL	no abnormal phenotype detected	J:101977
Sox17^tm1Jaw/Sox17^tm1Jaw Tg(Foxa3-cre)1Khk/0 involves: 129S6/SvEvTac * C57BL/6 * DBA	abnormal bile duct development	J:151981
	abnormal common bile duct morphology	J:151981
	absent gallbladder	J:151981
Sox17^tm1Jaw/Sox17^tm1Jaw Tg(Pdx1-cre)6Tuv/0 involves: 129S6/SvEvTac * FVB/N	abnormal bile duct development	J:151981
Sox17^tm1Jaw/Sox17^tm1Sjm Tg(Foxa3-cre)1Khk/0 involves: 129 * C57BL/6 * DBA	abnormal bile duct development	J:151981
Sox17^tm1Jaw/Sox17^tm1Sjm Tg(Pdx1-cre)6Tuv/0 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N	abnormal bile duct development	J:151981
	absent gallbladder	J:151981
Sox17^tm1Sjm/Sox17^tm1Sjm BKa.129-Sox17^tm1Sjm	abnormal embryo turning	J:123050
	abnormal embryonic hematopoiesis	J:123050
	abnormal rostral-caudal axis patterning	J:123050
	decreased hematopoietic stem cell number	J:123050
	embryonic growth retardation	J:123050
	embryonic lethality during organogenesis, complete penetrance	J:123050
	liver hypoplasia	J:123050
Sox17^tm1Sjm/Sox17^tm1Sjm involves: 129S1/Sv * 129X1/SvJ	abnormal bile duct development	J:151981
Sox17^tm1Sjm/Sox17^tm1Sjm involves: 129S1/Sv * 129X1/SvJ	absent pancreas	J:151981
Sox17^tm1Sjm/Sox17^tm2Sjm Tg(Mx1-cre)1Cgn/0 involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA	decreased bone marrow cell number	J:123050
	decreased hematopoietic stem cell number	J:123050
	decreased leukocyte cell number	J:123050
	postnatal lethality, complete penetrance	J:123050
	spleen hypoplasia	J:123050
	thrombocytopenia	J:123050
	thymus hypoplasia	J:123050
Sox17^tm1Sjm/Sox17^tm2Sjm Tg(Tek-cre)12Flv/0 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka	abnormal embryonic hematopoiesis	J:123050
	embryonic growth retardation	J:123050
	embryonic lethality during organogenesis, complete penetrance	J:123050
Sox17^tm1Ysk/Sox17⁺ B6.129S1-Sox17^tm1Ysk	abnormal bile duct development	J:194071
	abnormal extrahepatic bile duct morphology	J:194071
	abnormal gallbladder epithelium morphology	J:194071, J:241569
	abnormal gallbladder morphology	J:194071, J:241569
	abnormal gallbladder physiology	J:241569
	abnormal gallbladder smooth muscle morphology	J:241569
	abnormal hepatocyte morphology	J:194071
	abnormal liver development	J:194071
	abnormal liver lobule morphology	J:194071
	biliary atresia	J:241569
	cholestasis	J:194071, J:241569
	decreased liver weight	J:194071
	extrahepatic cholestasis	J:194071
	gallbladder inflammation	J:241569
	increased bile salt level	J:194071
	increased circulating alanine transaminase level	J:194071
	increased circulating alkaline phosphatase level	J:194071
	liver inflammation	J:194071
	neonatal lethality, incomplete penetrance	J:241569
	perinatal lethality, incomplete penetrance	J:194071
	small gallbladder	J:241569
Sox17^tm1Ysk/Sox17⁺ involves: 129S1/Sv * C57BL/6	abnormal extrahepatic bile duct morphology	J:194071
	abnormal gallbladder morphology	J:194071
	liver inflammation	J:194071
Sox17^tm1Ysk/Sox17^tm1Ysk involves: 129S1/Sv	abnormal endoderm development	J:75946
	abnormal foregut morphology	J:75946
	abnormal hindgut morphology	J:75946
	abnormal midgut morphology	J:75946
	abnormal rostral-caudal axis patterning	J:75946
	embryonic lethality during organogenesis, complete penetrance	J:75946
	failure of initiation of embryo turning	J:75946
	thin endoderm	J:75946
Sox17^{tm2.1(icre)Heli}/Sox17^{tm2.1(icre)Heli} involves: 129S6/SvEvTac * C57BL/6 * SJL	no abnormal phenotype detected	J:155991
Sox17^tm2Sjm/Sox17⁺ Tg(Pdx1-cre)6Tuv/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal cystic duct morphology	J:241569
	abnormal gallbladder epithelium morphology	J:241569
	abnormal gallbladder size	J:241569
	abnormal liver morphology	J:241569
	biliary atresia	J:241569
	cholestasis	J:241569
	liver inflammation	J:241569
Sox17^tm2Sjm/Sox17^tm2Sjm Tg(Cdh5-cre/ERT2)1Rha/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal abdominal aorta morphology	J:234137
	abnormal artery morphology	J:234137
	abnormal blood vessel endothelium morphology	J:234137
	abnormal thoracic aorta morphology	J:234137
	abnormal vascular smooth muscle morphology	J:234137
	aneurysm	J:234137
	aortic dissection	J:234137
	decreased endothelial cell proliferation	J:234137
	hemorrhage	J:234137
	increased vascular permeability	J:234137
Sox17^tm3.1Heli/Sox17^tm3.1Heli B6.Cg-Sox17^tm3.1Heli	no abnormal phenotype detected	J:185482

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