Sema4a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
MGI:107560

22 phenotypes from 7 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sema4a^{Gt(OST393408)Lex}/Sema4a^{Gt(OST393408)Lex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal eye electrophysiology	J:92305
	abnormal eye morphology	J:92305
	abnormal eye physiology	J:92305
	abnormal photoreceptor outer segment morphology	J:92305
	abnormal retina cone cell outer segment morphology	J:92305
	abnormal retina pigment epithelium morphology	J:92305
	abnormal retina rod cell outer segment morphology	J:92305
	decreased eye pigmentation	J:92305
	decreased retina photoreceptor cell number	J:92305
	retina degeneration	J:92305
	thin retina inner nuclear layer	J:92305
	thin retina inner plexiform layer	J:92305
	thin retina outer nuclear layer	J:92305
Sema4a^tm1.1Akum/Sema4a^tm1.1Akum involves: C57BL/6J	normal vision/eye phenotype	J:205754
Sema4a^{tm1b(EUCOMM)Wtsi}/Sema4a^{tm1b(EUCOMM)Wtsi} B6(Cg)-Sema4a^{tm1b(EUCOMM)Wtsi}	normal renal/urinary system phenotype	J:221423
Sema4a^tm1Kik/Sema4a^tm1Kik either: B6.Cg-Sema4a^tm1Kik or C.Cg-Sema4a^tm1Kik	abnormal CD4-positive, alpha-beta T cell physiology	J:97027
	abnormal cytokine secretion	J:97027
	abnormal dendritic cell antigen presentation	J:97027
	abnormal T-helper 1 cell differentiation	J:97027
	decreased susceptibility to type IV hypersensitivity reaction	J:97027
Sema4a^tm1Kik/Sema4a^tm1Kik Not Specified	absent photoreceptor outer segment	J:119485
	increased retina apoptosis	J:119485
	retina degeneration	J:119485
Sema4a^tm2.1Akum/Sema4a^tm2.1Akum involves: C57BL/6J	normal vision/eye phenotype	J:205754
Sema4a^tm2.1Akum/Sema4a^tm3.1Akum involves: C57BL/6J	normal vision/eye phenotype	J:205754
Sema4a^tm3.1Akum/Sema4a^tm3.1Akum involves: C57BL/6J	abnormal photoreceptor outer segment morphology	J:205754
	abnormal retina pigment epithelium morphology	J:205754
	absent photoreceptor outer segment	J:205754
	decreased retina photoreceptor cell number	J:205754
	increased retina apoptosis	J:205754
	retina degeneration	J:205754
Sema4a^tm4.1Akum/Sema4a^tm4.1Akum involves: C57BL/6J	normal vision/eye phenotype	J:205754

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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