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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gjb6
gap junction protein, beta 6
MGI:107588
32 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gjb6tm1.1Fama/Gjb6+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		normal hearing/vestibular/ear phenotype J:166362
Gjb6tm1.1Fama/Gjb6tm1.1Fama
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal cochlear potential J:166362
increased or absent threshold for auditory brainstem response J:166362
Gjb6tm1.1Mcsa/Gjb6tm1.1Mcsa
involves: 129 * BALB/c * C57BL/6 		normal hearing/vestibular/ear phenotype J:193913
Gjb6tm1Kwi/Gjb6+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal nervous system physiology J:89971
decreased dopamine level J:89971
Gjb6tm1Kwi/Gjb6tm1Kwi
involves: 129P2/OlaHsd 		deafness J:166362
decreased endocochlear potential J:166362
increased or absent threshold for auditory brainstem response J:166362
Gjb6tm1Kwi/Gjb6tm1Kwi
involves: 129P2/OlaHsd * C57BL/6 		abnormal amino acid level J:120823
abnormal blood-inner ear barrier function J:120823
abnormal cochlear endolymph ionic homeostasis J:80917
abnormal hair cell physiology J:178055
abnormal stria vascularis morphology J:120823
abnormal stria vascularis vasculature morphology J:120823
absent endocochlear potential J:80917
absent pinna reflex J:80917
cochlear hair cell degeneration J:80917
cochlear inner hair cell degeneration J:80917, J:119517
cochlear outer hair cell degeneration J:80917, J:119517
deafness J:119517
decreased endocochlear potential J:80917, J:119517
normal immune system phenotype J:85065
increased or absent threshold for auditory brainstem response J:80917, J:119517
organ of Corti degeneration J:119517
sensorineural hearing loss J:80917
Gjb6tm1Kwi/Gjb6tm1Kwi
involves: 129P2/OlaHsd * C57BL/6J 		abnormal nervous system physiology J:89971
decreased vertical activity J:89971
increased anxiety-related response J:89971
normal nervous system phenotype J:89971
Gjb6tm2.2Kwi/Gjb6tm2.2Kwi
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CD-1 * SJL 		abnormal epidermal layer morphology J:208123
abnormal sebaceous gland morphology J:208123
decreased threshold for auditory brainstem response J:208123
enlarged sebaceous gland J:208123
greasy coat J:208123
hyperkeratosis J:208123
impaired hearing J:208123
increased or absent threshold for auditory brainstem response J:208123
increased sebocyte number J:208123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory