Sp4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sp4
trans-acting transcription factor 4
MGI:107595

48 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^tm1(cre)Krc/Myl2⁺ Sp4^tm2Krc/Sp4^tm2Krc involves: 129S4/SvJae	abnormal heart morphology	J:107057
Sp4^tm1Krc/Sp4^tm1Krc involves: 129S4/SvJae * Black Swiss	abnormal heartbeat	J:77375
	abnormal impulse conducting system conduction	J:77375
	abnormal Purkinje fiber morphology	J:77375
	absent heartbeat	J:77375
	atrioventricular block	J:77375
	decreased body size	J:77375
	irregular heartbeat	J:77375
	postnatal lethality, incomplete penetrance	J:77375
	premature death	J:77375
	sinoatrial block	J:77375
	sinus bradycardia	J:77375
	ventricular premature beat	J:77375
	ventricular tachycardia	J:77375
Sp4^tm1Ssp/Sp4^tm1Ssp involves: 129P2/OlaHsd * CF-1	decreased body size	J:33573
	normal endocrine/exocrine gland phenotype	J:33573
	normal homeostasis/metabolism phenotype	J:33573
	male infertility	J:33573
	normal nervous system phenotype	J:33573
	postnatal lethality, incomplete penetrance	J:33573
	reduced male mating frequency	J:33573
	normal reproductive system phenotype	J:33573
	slow postnatal weight gain	J:33573
Sp4^tm1Sus/Sp4^tm1Sus involves: 129P2/OlaHsd * C57BL/6	delayed vaginal opening	J:77894
	normal hematopoietic system phenotype	J:77894
	normal homeostasis/metabolism phenotype	J:77894
	male infertility	J:77894
	postnatal growth retardation	J:77894
	postnatal lethality, incomplete penetrance	J:77894
	reduced female fertility	J:77894
	small testis	J:77894
	small uterus	J:77894
	spleen hypoplasia	J:77894
	thymus hypoplasia	J:77894
Sp4^tm2.1Krc/Sp4^tm2.1Krc involves: 129S4/SvJae * Black Swiss	abnormal impulse conducting system conduction	J:107057
	decreased body size	J:107057
	perinatal lethality, incomplete penetrance	J:107057
Sp4^tm2Krc/Sp4^tm2Krc Tg(Pax3-cre)1Joe/0 involves: C57BL/6 * SJL	abnormal impulse conducting system conduction	J:107057
	abnormal impulse conducting system morphology	J:107057
Sp4^tm3(Sp4)Krc/Sp4^tm3(Sp4)Krc involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal dentate gyrus morphology	J:110135
	abnormal hippocampus morphology	J:110135
	abnormal locomotor behavior	J:110135
	abnormal spatial reference memory	J:163637
	abnormal startle reflex	J:110135
	normal cardiovascular system phenotype	J:110135
	decreased exploration in new environment	J:110135
	decreased vertical activity	J:110135
	gliosis	J:110135
	hyperactivity	J:163637
	impaired contextual conditioning behavior	J:110135
	impaired coordination	J:110135
	impaired cued conditioning behavior	J:110135
	impaired passive avoidance behavior	J:110135
	impaired spatial learning	J:163637
	reduced long-term potentiation	J:163637
	reduced sensorimotor gating	J:110135

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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