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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Srebf1
sterol regulatory element binding transcription factor 1
MGI:107606
11 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Srebf1Gt(XC354)Byg/Srebf1Gt(XC354)Byg
either: B6.129P2-Srebf1Gt(XC354)Byg or (involves: 129P2/OlaHsd * C57BL/6) 		decreased liver triglyceride level J:152612
increased circulating ketone body level J:152612
Srebf1tm1Jdh/Srebf1tm1Jdh
involves: 129S/SvEvBrd * C57BL/6 		decreased survivor rate J:43570
embryonic lethality during organogenesis, incomplete penetrance J:43570
increased liver cholesterol level J:43570
lethality throughout fetal growth and development, incomplete penetrance J:43570
Srebf1tm1Mbr/Srebf1tm1Mbr
129S6(B6)-Srebf1tm1Mbr 		normal homeostasis/metabolism phenotype J:111873
Srebf1tm1Mbr/Srebf1tm1Mbr
involves: 129S6/SvEvTac 		decreased circulating cholesterol level J:75320
decreased circulating triglyceride level J:75320
increased liver cholesterol level J:75320
Srebf1tm1Mbr/Srebf1tm1Mbr
involves: 129S6/SvEvTac * C57BL/6J 		abnormal triglyceride level J:101307
decreased circulating cholesterol level J:101307
decreased circulating triglyceride level J:101307
Srebf1tm2Jdh/Srebf1tm2Jdh
involves: 129S/SvEvBrd * C57BL/6 		decreased circulating cholesterol level J:43570
decreased circulating triglyceride level J:43570
increased liver cholesterol level J:43570
postnatal lethality, incomplete penetrance J:43570
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory