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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il11
interleukin 11
MGI:107613
27 phenotypes from 3 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il11tm1Moto/Il11tm1Moto
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal compact bone morphology J:345337
abnormal fat cell differentiation J:345337
abnormal ossification involved in bone remodeling J:345337
abnormal trabecular bone morphology J:345337
abnormal vertebrae morphology J:345337
abnormal white fat cell morphology J:345337
decreased adiponectin level J:345337
decreased bone mass J:345337
decreased bone mineral density J:345337
decreased bone mineral density of femur J:345337
decreased bone mineral density of vertebrae J:345337
decreased bone ossification J:345337
female infertility J:345337
normal growth/size/body region phenotype J:345337
impaired glucose tolerance J:345337
impaired osteoblast differentiation J:345337
increased bone marrow adipose tissue amount J:345337
increased circulating leptin level J:345337
increased fat cell size J:345337
increased white adipose tissue amount J:345337
increased white fat cell number J:345337
insulin resistance J:345337
Il11tm2.1Moto/Il11tm2.1Moto
Tg(Adipoq-cre)1Evdr/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/NJ 		normal adipose tissue phenotype J:345337
normal homeostasis/metabolism phenotype J:345337
normal skeleton phenotype J:345337
Il11tm2.1Moto/Il11tm2.1Moto
Tg(BGLAP-cre)1Clem/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/NJ 		abnormal circulating interleukin level J:345337
abnormal ossification involved in bone remodeling J:345337
decreased bone mass J:345337
decreased bone mineral density J:345337
decreased circulating osteocalcin level J:345337
impaired glucose tolerance J:345337
increased white adipose tissue amount J:345337
insulin resistance J:345337
Il11tm2Moto/Il11tm2Moto
involves: C57BL/6NCrlj * CBA/JNCrlj 		female infertility J:345337
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory