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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifngr1
interferon gamma receptor 1
MGI:107655
84 phenotypes from 7 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ifngr1em1(IMPC)Mbp/Ifngr1em1(IMPC)Mbp
C57BL/6N-Ifngr1em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal skin morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
preweaning lethality, incomplete penetrance J:211773
Ifngr1m1Btlr/Ifngr1m1Btlr
C57BL/6J-Ifngr1m1Btlr 		decreased macrophage cell number J:236694
decreased tumor necrosis factor secretion J:236694
impaired hematopoiesis J:236694
increased B cell number J:236694
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio 		increased susceptibility to bacterial infection J:206257
increased susceptibility to bacterial infection induced morbidity/mortality J:206257
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Tg(Itgax-cre,-EGFP)4097Ach/0
B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach 		decreased interferon-gamma secretion J:206257
decreased interleukin-12b secretion J:206257
increased susceptibility to bacterial infection J:206257
increased susceptibility to bacterial infection induced morbidity/mortality J:206257
Ifngr1tm1.1Rost/Ifngr1tm1.1Rost
involves: BALB/cJ * C57BL/6 		abnormal chemokine level J:152785
decreased circulating interferon-gamma level J:152785
decreased circulating interleukin-12 level J:152785
decreased metastatic potential J:152785
normal immune system phenotype J:152785
Ifngr1tm1.2Rds/Ifngr1tm1.2Rds
C57BL/6NTac-Ifngr1tm1.2Rds 		decreased interleukin-12b secretion J:206257
increased susceptibility to bacterial infection J:206257
increased susceptibility to bacterial infection induced morbidity/mortality J:206257
Ifngr1tm1Agt/Ifngr1tm1Agt
129-Ifngr1tm1Agt/J 		normal immune system phenotype J:286237
Ifngr1tm1Agt/Ifngr1tm1Agt
B6.129S7-Ifngr1tm1Agt 		abnormal myelination J:108669
abnormal pain threshold J:158280
decreased physiological sensitivity to xenobiotic J:108669
Ifngr1tm1Agt/Ifngr1tm1Agt
B6.129S7-Ifngr1tm1Agt/J 		abnormal circulating chemokine level J:152785
abnormal depression-related behavior J:147443
abnormal hematopoietic system physiology J:138728
abnormal lymphopoiesis J:138728
abnormal osteoclast differentiation J:233116
decreased bone marrow cell number J:138728
decreased bone mineralization J:233116
decreased bone ossification J:233116
decreased bone resorption J:233116
decreased bone trabecula number J:233116
decreased bone volume J:233116
decreased CD4-positive, alpha-beta T cell number J:138728
decreased CD8-positive, alpha-beta T cell number J:138728
decreased circulating interleukin-12 level J:152785
decreased circulating osteocalcin level J:233116
decreased compact bone thickness J:233116
decreased lymphocyte cell number J:138728
decreased osteoblast cell number J:233116
decreased osteocyte number J:233116
decreased susceptibility to bacterial infection J:147443
decreased trabecular bone thickness J:233116
impaired osteoblast differentiation J:233116
increased interferon-gamma secretion J:138728
increased metastatic potential J:152785
increased susceptibility to graft versus host disease J:138728
increased susceptibility to induced morbidity/mortality J:138728
osteoporosis J:233116
spleen hypoplasia J:138728
Ifngr1tm1Agt/Ifngr1tm1Agt
involves: 129S7/SvEvBrd 		abnormal immunoglobulin level J:38363, J:101427
abnormal maternal decidual layer morphology J:56503
abnormal response to infection J:115139
abnormal tumor susceptibility J:63089
abnormal tumor vascularization J:63089
abnormal uterine NK cell morphology J:56503
abnormal uterine NK cell physiology J:56503
abnormal uterus morphology J:56503
abnormal vascular endothelial cell physiology J:114203
aortitis J:115139
arteritis J:115139
decreased circulating tumor necrosis factor level J:17878
decreased IgG2a level J:38363
decreased susceptibility to endotoxin shock J:17878
increased circulating interferon-gamma level J:314959
increased circulating interleukin-1 beta level J:314959
increased circulating interleukin-6 level J:174397
increased hepatocyte proliferation J:38363
increased interferon-gamma secretion J:38363
increased susceptibility to bacterial infection J:174397, J:314959
increased susceptibility to bacterial infection induced morbidity/mortality J:174397, J:314959
increased susceptibility to experimental autoimmune encephalomyelitis J:38363
increased susceptibility to Herpesvirales infection J:81243
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:115139
increased susceptibility to induced morbidity/mortality J:38363
increased susceptibility to parasitic infection J:114203
increased susceptibility to Poxviridae infection J:101427
increased tumor necrosis factor secretion J:38363
increased uterine NK cell number J:56503
liver abscess J:174397
Ifngr1tm1Agt/Ifngr1tm1Agt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cytotoxic T cell physiology J:63815
abnormal tumor susceptibility J:138466
decreased IgG2a level J:63815
decreased IgG3 level J:63815
decreased susceptibility to experimental autoimmune myasthenia gravis J:53577
increased interferon-gamma secretion J:99347
increased interleukin-6 secretion J:99347
increased splenocyte proliferation J:99347
increased susceptibility to bacterial infection J:63815
increased susceptibility to experimental autoimmune uveoretinitis J:99347
increased susceptibility to Riboviria infection J:63815
increased susceptibility to Riboviria infection induced morbidity/mortality J:63815
normal liver/biliary system phenotype J:120559
Ifngr1tm1Agt/Ifngr1tm1Agt
involves: 129S7/SvEvBrd * DBA/1OlaHsd 		decreased IgG2a level J:40634
increased susceptibility to induced arthritis J:40634
Ifngr1tm1Dmer/Ifngr1tm1Dmer
B6.Cg-Ifngr1tm1Dmer 		abnormal response to infection J:202844
Ifngr1tm1Dmer/Ifngr1tm1Dmer
Tg(Thy1-cre)1Vln/0
B6.Cg-Ifngr1tm1Dmer Tg(Thy1-cre)1Vln 		abnormal response to infection J:202844
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory