Ifng Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ifng
interferon gamma
MGI:107656

94 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Ifng^tm1Ts/Ifng^tm1Ts B6.129-Apoe^tm1Unc Ifng^tm1Ts	dilated aorta	J:166204
	increased body weight	J:166204
	increased susceptibility to induced aneurysm formation	J:166204
	increased susceptibility to induced morbidity/mortality	J:166204
Casp3^tm1Flv/Casp3^tm1Flv Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal lung volume	J:100854
	emphysema	J:100854
	increased apoptosis	J:100854
	increased lung compliance	J:100854
	increased lymphocyte cell number	J:100854
	increased macrophage cell number	J:100854
	increased neutrophil cell number	J:100854
Csf2^tm1Dran/Csf2^tm1Dran Ifng^tm1Ts/Ifng^tm1Ts Il3^tm1Glli/Il3^tm1Glli involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	increased B cell derived lymphoma incidence	J:83086
	increased carcinoma incidence	J:83086
	increased eosinophil cell number	J:83086
	increased IgE level	J:83086
	increased IgG1 level	J:83086
	increased immunoglobulin level	J:83086
	increased inflammatory response	J:83086
	increased ovarian carcinoma incidence	J:83086
	postnatal lethality, incomplete penetrance	J:83086
	premature death	J:83086
Csf2^tm1Mlg/Csf2^tm1Mlg Ifng^tm1Ts/Ifng^tm1Ts Il3^tm1Glli/Il3^tm1Glli B6.129S-Csf2^tm1Mlg Il3^tm1Glli Ifng^tm1TsIfng^tm1Ts	normal homeostasis/metabolism phenotype	J:145518
	increased pituitary adenoma incidence	J:145518
Ctss^tm1Hap/Ctss^tm1Hap Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0 involves: 129S2/SvPas * C57BL/6 * CBA	abnormal lung volume	J:100854
	emphysema	J:100854
	increased apoptosis	J:100854
	increased lung compliance	J:100854
	increased lymphocyte cell number	J:100854
	increased macrophage cell number	J:100854
	increased neutrophil cell number	J:100854
Eif2ak3^tm1Dron/Eif2ak3⁺ Tg(GFAP-tTA)110Pop/0 Tg(tetO-Ifng)184Pop/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster	abnormal myelination	J:99655
	abnormal oligodendrocyte apoptosis	J:99655
	abnormal oligodendrocyte morphology	J:99655
	abnormal spinal cord white matter morphology	J:99655
	increased spinal cord apoptosis	J:99655
	postnatal growth retardation	J:99655
	premature death	J:99655
	tonic seizures	J:99655
	tremors	J:99655
Eif2ak3^tm1Dron/Eif2ak3^tm1Dron Tg(GFAP-tTA)110Pop/0 Tg(tetO-Ifng)184Pop/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster	postnatal lethality, complete penetrance	J:99655
Fas^lpr/Fas^lpr Ifng^tm1Ts/Ifng⁺ MRL.Cg-Ifng^tm1Ts Fas^lpr	abnormal glomerular capillary morphology	J:123834
	abnormal macrophage chemotaxis	J:123834
	abnormal renal glomerulus morphology	J:123834
	glomerulonephritis	J:123834
	increased autoantibody level	J:123834
	increased blood urea nitrogen level	J:123834
	increased mesangial cell number	J:123834
	premature death	J:123834
Fas^lpr/Fas^lpr Ifng^tm1Ts/Ifng^tm1Ts involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp	abnormal lymph node size	J:39600
	abnormal spleen size	J:39600
	decreased anti-double stranded DNA antibody level	J:39600
	decreased anti-nuclear antigen antibody level	J:39600
	decreased autoantibody level	J:39600
	decreased circulating creatinine level	J:39600
	decreased double-negative T cell number	J:39600
	decreased IgA level	J:39600
	decreased IgG2a level	J:39600
	decreased IgG2b level	J:39600
	decreased IgM level	J:39600
	decreased immunoglobulin level	J:39600
	decreased susceptibility to systemic lupus erythematosus	J:39600
	enlarged lymph nodes	J:39600
	enlarged spleen	J:39600
Fas^lpr/Fas^lpr Ifng^tm1Ts/Ifng^tm1Ts MRL.Cg-Ifng^tm1Ts Fas^lpr	abnormal macrophage chemotaxis	J:123834
	abnormal renal glomerulus morphology	J:123834
	normal immune system phenotype	J:123834
	kidney inflammation	J:123834
	lung inflammation	J:123834
Foxo1^tm1Flv/Foxo1^tm1Flv Ifng^tm1Ts/Ifng^tm1Ts Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	normal immune system phenotype	J:189962
	increased CD4-positive, alpha-beta T cell number	J:189962
	increased CD8-positive, alpha-beta T cell number	J:189962
	normal mortality/aging	J:189962
Ifng^{tm1(Thy1)Weav}/? involves: C57BL/6	no abnormal phenotype detected	J:144542
Ifng^tm1Ts/Ifng⁺ Socs1^tm1Wehi/Socs1^tm1Wehi involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	decreased survivor rate	J:57474
	premature death	J:57474
Ifng^tm1Ts/Ifng^tm1Ts Ldlr^tm1Her/Ldlr^tm1Her B6.129S7-Ldlr^tm1Her Ifng^tm1Ts	atherosclerotic lesions	J:103072
	increased T cell number	J:103072
Ifng^tm1Ts/Ifng^tm1Ts Nlrp1a^Neut1/Nlrp1a^Neut1 involves: 129S7/SvEvBrd * C57BL/6	brain inflammation	J:191055
	normal immune system phenotype	J:191055
Ifng^tm1Ts/Ifng^tm1Ts Pld4^tm1.2Nemz/Pld4^tm1.2Nemz involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N	decreased NK T cell number	J:281205
	normal hematopoietic system phenotype	J:281205
	increased susceptibility to induced morbidity/mortality	J:281205
Ifng^tm1Ts/Ifng^tm1Ts Prf1^tm1Sdz/Prf1^tm1Sdz C.Cg-Prf1^tm1Sdz Ifng^tm1Ts	abnormal tumor morphology	J:77491
	decreased tumor latency	J:77491
	increased B cell derived lymphoma incidence	J:77491
	increased lymphoma incidence	J:77491
	premature death	J:77491
Ifng^tm1Ts/Ifng^tm1Ts Socs1^tm1Jni/Socs1^tm1Jni involves: 129S7/SvEvBrd	increased interleukin-17 secretion	J:132905
Ifng^tm1Ts/Ifng^tm1Ts Socs1^tm1Wehi/Socs1^tm1Wehi involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	abnormal lactation	J:70408
	abnormal lung vasculature morphology	J:57474
	abnormal mammary gland growth during pregnancy	J:70408
	enlarged thymus medulla	J:57474
	normal hematopoietic system phenotype	J:57474
	mammary gland alveolar hyperplasia	J:70408
	normal mortality/aging	J:57474, J:70408
Ifng^tm1Ts/Ifng^tm1Ts Tg(SFTPC-Il18)AThos/0 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2	abnormal lung volume	J:147547
	abnormal pulmonary alveolus morphology	J:147547
	emphysema	J:147547
	lung inflammation	J:147547
Ifng^tm1Ts/Ifng^tm1Ts Tgfb1^tm1Doe/Tgfb1^tm1Doe C.129-Ifng^tm1Ts Tgfb1^tm1Doe	cachexia	J:69346
	decreased body weight	J:69346
	increased circulating alanine transaminase level	J:69346
	liver inflammation	J:69346
	normal liver/biliary system phenotype	J:69346
	premature death	J:69346
Ifng^tm1Ts/Ifng^tm1Ts Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 Tg(Cd4-cre)1Cwi/0 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL	normal immune system phenotype	J:196160
	normal mortality/aging	J:196160
Ifng^tm1Ts/Ifng^tm1Ts Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J	small intestinal inflammation	J:108572
Ifng^tm1Ts/Ifng^tm1Ts Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	abnormal lymph node cortex morphology	J:119206
	abnormal lymph node primary follicle morphology	J:119206
	abnormal lymph node secondary follicle morphology	J:119206
	absent lymph node germinal center	J:119206
	absent spleen germinal center	J:119206
	increased eosinophil cell number	J:119206
	increased leukocyte cell number	J:119206
	increased lymphocyte cell number	J:119206
	increased susceptibility to fungal infection	J:119206
	lung inflammation	J:119206
	small Peyer's patches	J:119206
Stat1^tm1Rds/Stat1^tm1Rds Tg(GFAP-tTA)67Pop/0 Tg(tetO-Ifng)184Pop/0 involves: 129S/SvEv * C57BL/6 * DBA/2	ataxia	J:94092
	normal mortality/aging	J:94092
	normal neoplasm	J:94092
	prenatal lethality, complete penetrance	J:94092
	tremors	J:94092

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