Ifnb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ifnb1
interferon beta 1, fibroblast
MGI:107657

46 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp B6.129P2-Ifnb1^tm1Acgp	abnormal macrophage physiology	J:136368
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp B6.129P2-Ifnb1^tm1Acgp	decreased interleukin-1 beta secretion	J:136368
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp involves: 129P2/OlaHsd	abnormal spleen primary B follicle morphology	J:86527
	decreased common myeloid progenitor cell number	J:86527
	decreased erythroid progenitor cell number	J:86527
	decreased macrophage cell number	J:86527
	decreased mature B cell number	J:86527
	decreased monocyte cell number	J:86527
	decreased neutrophil cell number	J:86527
	decreased pro-B cell number	J:86527
	decreased tumor necrosis factor secretion	J:86527
	increased T cell proliferation	J:86527
	increased tumor growth/size	J:86527
Ifnb1^tm1Acgp/Ifnb1^tm1Acgp involves: 129P2/OlaHsd * C57BL/6	decreased circulating interferon-beta level	J:61048
	increased susceptibility to Poxviridae infection	J:61048
Ifnb1^tm1Lky/Ifnb1^tm1Lky involves: 129 * C57BL/6	no abnormal phenotype detected	J:152138
Ifnb1^tm1Tl/Ifnb1^tm1Tl B6.129P2-Ifnb1^tm1Tl	decreased circulating interferon-alpha level	J:172226
	decreased circulating interferon-beta level	J:172226
	decreased susceptibility to bacterial infection	J:172226
Ifnb1^tm1Tl/Ifnb1^tm1Tl B10.129P2-Ifnb1^tm1Tl	abnormal macrophage physiology	J:83021
	abnormal microglial cell physiology	J:83021
	CNS inflammation	J:83021
	demyelination	J:83021
	increased interferon-gamma secretion	J:83021
	increased interleukin-4 secretion	J:83021
	increased susceptibility to experimental autoimmune encephalomyelitis	J:83021
	increased tumor necrosis factor secretion	J:83021
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg B6.Cg-Ifnb1^tm1Ttg	abnormal osteoclast morphology	J:76097
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg B6.Cg-Ifnb1^tm1Ttg	decreased bone mineral density	J:76097
Ifnb1^tm1Ttg/Ifnb1^tm1Ttg involves: C57BL/6	abnormal response to infection	J:116703
Tg(CAG-C1qtnf6)#Yiw/0 involves: C57BL/6JJcl	abnormal complement protein level	J:227217
	decreased IgG level	J:227217
	decreased susceptibility to induced arthritis	J:227217
	impaired complement alternative pathway	J:227217
	normal renal/urinary system phenotype	J:227217
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif C3H/HeOuJ-Tg(H2-K1-Ifnb1)10Seif	abnormal male germ cell apoptosis	J:174828
	abnormal male reproductive system physiology	J:174828
	abnormal seminiferous tubule morphology	J:174828
	abnormal spermiogenesis	J:174828
	abnormal testis morphology	J:174828
	decreased litter size	J:174828
	decreased testis weight	J:174828
	early reproductive senescence	J:174828
	male infertility	J:174828
	oligozoospermia	J:174828
	reduced male fertility	J:174828
	normal reproductive system phenotype	J:174828
	seminiferous tubule degeneration	J:174828

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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