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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
58 phenotypes from 5 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ifnar1tm1Uka/Ifnar1tm1Uka
B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka 		decreased IgG1 level J:129128
decreased IgG2a level J:129128
decreased IgG3 level J:129128
decreased IgM level J:129128
Ifnar1m1Btlr/Ifnar1m1Btlr
C57BL/6J-Ifnar1m1Btlr 		abnormal macrophage physiology J:142790
decreased interferon-alpha secretion J:142790
decreased interferon-beta secretion J:142790
normal immune system phenotype J:142790
increased susceptibility to Adenoviridae infection J:142790
increased susceptibility to Herpesvirales infection J:142790
increased susceptibility to Orthomyxoviridae infection J:142790
increased susceptibility to Riboviria infection J:142790
Ifnar1m2Btlr/Ifnar1m2Btlr
involves: C57BL/6J 		decreased interferon-beta secretion J:198556
Ifnar1tm1Agt/Ifnar1tm1Agt
B6.129S2-Ifnar1tm1Agt 		abnormal osteoclast morphology J:76097
abnormal response to infection J:116703
decreased bone mineral density J:76097
decreased interferon-alpha secretion J:125611
decreased interferon-beta secretion J:125611
decreased interleukin-6 secretion J:199862
decreased tumor necrosis factor secretion J:199862
impaired natural killer cell mediated cytotoxicity J:118750
increased susceptibility to bacterial infection induced morbidity/mortality J:199862
increased tumor growth/size J:118750
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S2/SvPas 		abnormal cytokine secretion J:114555
abnormal dendritic cell physiology J:114555
abnormal gait J:160878
abnormal immunoglobulin level J:101427
abnormal inflammatory response J:114555
abnormal NK cell physiology J:79552, J:139001
cornea vascularization J:114973
normal immune system phenotype J:286237
impaired natural killer cell mediated cytotoxicity J:79552
increased circulating alanine transaminase level J:144400
increased susceptibility to Coronaviridae infection J:144400
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:144400
increased susceptibility to Herpesvirales infection J:81243, J:197569
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:115139
increased susceptibility to Paramyxoviridae infection J:160878
increased susceptibility to Paramyxoviridae infection induced morbidity/mortality J:160878
increased susceptibility to Picornaviridae infection J:137522
increased susceptibility to Poxviridae infection J:101427
induced hyperactivity J:160878
lethargy J:160878
liver hemorrhage J:144400
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S2/SvPas * 129S6/SvEvTac 		abnormal CD8-positive, alpha-beta T cell physiology J:54482
abnormal interferon-gamma secretion J:54482
increased circulating interleukin-12 level J:54482
increased susceptibility to Riboviria infection J:54482
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S2/SvPas * BALB/c 		abnormal cytokine level J:291874
abnormal mononuclear phagocyte morphology J:291874
decreased Ly6C high monocyte number J:291874
decreased susceptibility to Coronaviridae infection J:291874
decreased T cell apoptosis J:291874
increased CD4-positive, alpha-beta T cell number J:291874
increased CD8-positive, alpha-beta T cell number J:291874
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:291874
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:291874
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL 		increased susceptibility to Orthomyxoviridae infection J:119783
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S2/SvPas * C57BL/6 		abnormal susceptibility to infection J:120938
normal immune system phenotype J:238323
Ifnar1tm1Pjh/Ifnar1tm1Pjh
B6.129S2-Ifnar1tm1Pjh 		decreased NK cell number J:125812
impaired natural killer cell mediated cytotoxicity J:125812
increased incidence of induced tumors J:125812
increased incidence of tumors by chemical induction J:125812
Ifnar1tm1Pjh/Ifnar1tm1Pjh
involves: 129S2/SvPas * BALB/c 		abnormal enzyme/coenzyme activity J:36004
abnormal macrophage physiology J:36004
increased leukocyte cell number J:36004
increased susceptibility to Picornaviridae infection J:36004
increased susceptibility to Picornaviridae infection induced morbidity/mortality J:36004
increased susceptibility to Togaviridae infection J:36004
increased susceptibility to Togaviridae infection induced morbidity/mortality J:36004
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory