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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abcg1
ATP binding cassette subfamily G member 1
MGI:107704
37 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abcg1tm1Asch/Abcg1tm1Asch
involves: 129X1/SvJ * C57BL/6 		abnormal brown adipose tissue morphology J:122438
abnormal fat cell morphology J:122438
decreased susceptibility to diet-induced hepatic steatosis J:122438
decreased susceptibility to diet-induced obesity J:122438
hypoglycemia J:122438
increased body temperature J:122438
increased energy expenditure J:122438
increased locomotor activity J:122438
increased oxygen consumption J:122438
Abcg1tm1Dgen/Abcg1tm1Dgen
B6.129P2-Abcg1tm1Dgen 		abnormal lung morphology J:117028
abnormal macrophage physiology J:117028
abnormal phospholipid level J:117028
hepatic steatosis J:117028
increased liver cholesterol level J:117028
increased liver triglyceride level J:117028
increased lung cholesterol level J:117028
increased macrophage derived foam cell number J:117028
increased triglyceride level J:117028
normal renal/urinary system phenotype J:117028
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd 		abnormal lipid level J:141549
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		abnormal chemokine secretion J:130777
abnormal cytokine secretion J:130777
abnormal leukocyte morphology J:132952
abnormal lung morphology J:132952
abnormal macrophage morphology J:132952
abnormal monocyte differentiation J:132952
abnormal surfactant secretion J:132952
decreased cholesterol efflux J:130777
increased B cell number J:132952
increased CD4-positive, alpha-beta T cell number J:132952
increased CD8-positive, alpha-beta T cell number J:132952
increased dendritic cell number J:132952
increased eosinophil cell number J:132952
increased monocyte cell number J:132952
increased neutrophil cell number J:132952
lipidosis J:132952
lung inflammation J:132952
overexpanded pulmonary alveolus J:132952
Tg(Abcg1)80-90Ssf/?
C57BL/6-Tg(Abcg1)80-90Ssf 		abnormal phospholipid level J:94077
increased liver cholesterol level J:94077
Tg(Abcg1)123Ssf/?
C57BL/6-Tg(Abcg1)123Ssf 		abnormal phospholipid level J:94077
increased liver cholesterol level J:94077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory