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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myh9
myosin, heavy polypeptide 9, non-muscle
MGI:107717
69 phenotypes from 15 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myh9Gt(Betageo-btk)1Dash/Myh9+
involves: 129X1/SvJ * C57BL/6 		normal hematopoietic system phenotype J:94067
impaired hearing J:94067
increased or absent threshold for auditory brainstem response J:94067
normal renal/urinary system phenotype J:94067
Myh9Gt(Betageo-btk)1Dash/Myh9Gt(Betageo-btk)1Dash
involves: 129X1/SvJ * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:94067
Myh9Gt(RRE342)Byg/Myh9+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:110432
Myh9Gt(RRE342)Byg/Myh9Gt(RRE342)Byg
involves: 129P2/OlaHsd * C57BL/6 		prenatal lethality, complete penetrance J:110432
Myh9tm1(mCherry/MYH9)Rsad/Myh9tm1(mCherry/MYH9)Rsad
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:163702
Myh9tm1.1(MYH9*)Mjk/Myh9+
B6.Cg-Myh9tm1.1(MYH9*)Mjk 		abnormal eye physiology J:175367
abnormal lens fiber morphology J:175367
abnormal neutrophil morphology J:175367
abnormal platelet morphology J:175367
albuminuria J:175367
cataract J:175367
cornea vascularization J:175367
increased bleeding time J:175367
increased incidence of corneal inflammation J:175367
increased or absent threshold for auditory brainstem response J:175367
increased susceptibility to age-related hearing loss J:175367
thrombocytopenia J:175367
Myh9tm1.1(MYH9*)Mjk/Myh9tm1.1(MYH9*)Mjk
B6.129-Myh9tm1.1(MYH9*)Mjk 		abnormal megakaryocyte morphology J:175367
abnormal neutrophil morphology J:175367
abnormal platelet morphology J:175367
albuminuria J:175367
glomerulosclerosis J:175367
increased bleeding time J:175367
thrombocytopenia J:175367
Myh9tm1.1Dash/Myh9+
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA 		abnormal lens fiber morphology J:204923
abnormal megakaryocyte differentiation J:204923
abnormal platelet morphology J:204923
abnormal thrombopoiesis J:204923
albuminuria J:204923
glomerulosclerosis J:204923
normal hearing/vestibular/ear phenotype J:204923
hematuria J:204923
normal homeostasis/metabolism phenotype J:204923
increased or absent threshold for auditory brainstem response J:204923
podocyte foot process effacement J:204923
preweaning lethality, complete penetrance J:204923
thrombocytopenia J:204923
normal vision/eye phenotype J:204923
Myh9tm1.1Dash/Myh9tm1.1Dash
involves: 129S2/SvPas * C57BL/6 * CBA 		prenatal lethality, complete penetrance J:204923
Myh9tm1.1Gac/Myh9+
Tg(Pf4-icre)Q3Rsko/0
involves: 129 * C57BL/6 		abnormal platelet physiology J:148233
Myh9tm1.1Gac/Myh9tm1.1Gac
Tg(NPHS2-cre)295Lbh/0
involves: 129 * C57BL/6 * SJL 		albuminuria J:173971
normal cardiovascular system phenotype J:173971
fused podocyte foot processes J:173971
glomerulosclerosis J:173971
normal growth/size/body region phenotype J:173971
normal homeostasis/metabolism phenotype J:173971
increased renal glomerulus basement membrane thickness J:173971
increased susceptibility to injury J:173971
podocyte foot process effacement J:173971
podocyte microvillus transformation J:173971
renal cast J:173971
normal renal/urinary system phenotype J:173971
Myh9tm1.1Gac/Myh9tm1.1Gac
Tg(Pf4-icre)Q3Rsko/0
involves: 129 * C57BL/6 		abnormal blood coagulation J:148233
abnormal platelet morphology J:148233
abnormal platelet physiology J:148233
abnormal platelet shape J:148233
increased bleeding time J:148233
increased susceptibility to induced morbidity/mortality J:148233
thrombocytopenia J:148233
Myh9tm1.2Gac/Myh9tm1.2Gac
involves: 129 		normal hematopoietic system phenotype J:195436
Myh9tm1Maco/Myh9tm1Maco
involves: 129X1/SvJ 		abnormal germ layer development J:94940, J:163702
abnormal visceral endoderm morphology J:94940, J:163702
embryonic lethality between implantation and somite formation, complete penetrance J:94940, J:163702
failure to gastrulate J:163702
Myh9tm2(GFP/MYH10)Rsad/Myh9tm2(GFP/MYH10)Rsad
involves: 129S4/SvJae * C57BL/6 		abnormal actin cytoskeleton morphology J:163702
abnormal brain vasculature morphology J:163702
abnormal cell adhesion J:163702
abnormal cell migration J:163702
abnormal placenta labyrinth morphology J:163702
abnormal placenta morphology J:163702
abnormal placenta size J:163702
abnormal placental labyrinth vasculature morphology J:163702
abnormal spongiotrophoblast layer morphology J:163702
abnormal vascular branching morphogenesis J:163702
abnormal vitelline vasculature morphology J:163702
normal embryo phenotype J:163702
embryonic growth retardation J:163702
embryonic lethality during organogenesis, complete penetrance J:163702
pale yolk sac J:163702
Myh9tm3(GFP/MYH9/MYH10)Rsad/Myh9tm3(GFP/MYH9/MYH10)Rsad
involves: 129S4/SvJae * C57BL/6 		abnormal actin cytoskeleton morphology J:163702
abnormal cell adhesion J:163702
abnormal cell migration J:163702
abnormal placental labyrinth vasculature morphology J:163702
abnormal vitelline vasculature morphology J:163702
normal embryo phenotype J:163702
embryonic lethality during organogenesis, complete penetrance J:163702
pale yolk sac J:163702
thin placenta labyrinth J:163702
Myh9tm4(GFP/MYH10/MYH9)Rsad/Myh9tm4(GFP/MYH10/MYH9)Rsad
involves: 129S4/SvJae * C57BL/6 		abnormal actin cytoskeleton morphology J:163702
abnormal cell adhesion J:163702
abnormal cell migration J:163702
abnormal placenta labyrinth morphology J:163702
abnormal placenta morphology J:163702
abnormal placenta size J:163702
abnormal placental labyrinth vasculature morphology J:163702
abnormal spongiotrophoblast layer morphology J:163702
abnormal vitelline vasculature morphology J:163702
normal embryo phenotype J:163702
embryonic lethality during organogenesis, complete penetrance J:163702
pale yolk sac J:163702
Myh9tm5Rsad/Myh9tm5Rsad
involves: 129S6/SvEvTac * C57BL/6J 		abnormal leukocyte migration J:164684
abnormal T cell physiology J:164684
Myh9tm5Rsad/Myh9tm5Rsad
Tg(Lck-cre)#Nik/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 		abnormal CD8-positive, alpha-beta T cell physiology J:164684
abnormal leukocyte adhesion J:164684
abnormal leukocyte migration J:164684
abnormal lymph node cell ratio J:164684
abnormal T cell physiology J:164684
decreased CD8-positive, alpha-beta T cell number J:164684
Myh9tm5Rsad/Myh9tm5Rsad
Tg(Nphs2-cre)1Seq/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal podocyte morphology J:175367
albuminuria J:175367
glomerulosclerosis J:175367
podocyte foot process effacement J:175367
Myh9tm6.1(EGFP/MYH9*)Rsad/Myh9+
involves: 129S4/SvJae * BALB/cJ * C57BL/6 		abnormal blood coagulation J:175367
abnormal neutrophil morphology J:175367
abnormal platelet morphology J:175367
increased bleeding time J:175367
increased megakaryocyte cell number J:175367
thrombocytopenia J:175367
Myh9tm6.1(EGFP/MYH9*)Rsad/Myh9tm6.1(EGFP/MYH9*)Rsad
involves: 129S4/SvJae * BALB/cJ * C57BL/6 		abnormal placenta fetal blood space morphology J:175367
abnormal placenta intervillous maternal lacunae morphology J:175367
decreased embryo size J:175367
embryonic growth retardation J:175367
embryonic lethality during organogenesis, complete penetrance J:175367
Myh9tm7.1Rsad/Myh9+
involves: BALB/cJ 		abnormal neutrophil morphology J:175367
abnormal platelet morphology J:175367
albuminuria J:175367
cataract J:175367
glomerulosclerosis J:175367
increased bleeding time J:175367
increased megakaryocyte cell number J:175367
thrombocytopenia J:175367
Myh9tm7.1Rsad/Myh9tm7.1Rsad
involves: BALB/cJ 		abnormal megakaryocyte morphology J:175367
abnormal neutrophil morphology J:175367
abnormal platelet morphology J:175367
albuminuria J:175367
cataract J:175367
glomerulosclerosis J:175367
increased bleeding time J:175367
increased megakaryocyte cell number J:175367
thrombocytopenia J:175367
Myh9tm8.1Rsad/Myh9+
involves: BALB/cJ 		glomerulosclerosis J:175367
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory