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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
MGI:107799
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Gadd45atm1Ajf/Gadd45atm1Ajf
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6 		abnormal centrosome morphology J:91673
aneuploidy J:91673
embryonic growth retardation J:91673
exencephaly J:91673
prenatal lethality, complete penetrance J:91673
Cdkn1atm1Led/Cdkn1atm1Led
Gadd45atm1Ajf/Gadd45atm1Ajf
either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6) 		abnormal chromosome number J:57882
abnormal glomerular capillary endothelium morphology J:76041
abnormal lymphopoiesis J:76041
abnormal T cell activation J:76041
decreased basophil cell number J:76041
decreased eosinophil cell number J:76041
decreased leukocyte cell number J:76041
decreased lymphocyte cell number J:76041
dilated proximal convoluted tubule J:76041
glomerulonephritis J:76041
increased anti-double stranded DNA antibody level J:76041
increased anti-histone antibody level J:76041
increased anti-single stranded DNA antibody level J:76041
increased autoantibody level J:76041
increased fibroblast proliferation J:57882
increased IgG1 level J:76041
increased IgM level J:76041
increased inflammatory response J:76041
increased kidney cell proliferation J:76041
increased mesangial cell number J:76041
increased T cell proliferation J:76041
increased urine protein level J:76041
mesangial cell interposition J:76041
premature death J:76041
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Gadd45atm1Ajf/Gadd45atm1Ajf
either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ) 		decreased cellular sensitivity to ultraviolet irradiation J:101710
normal homeostasis/metabolism phenotype J:101710
Gadd45atm1Ajf/Gadd45atm1Ajf
Gadd45btm1Daa/Gadd45btm1Daa
Gadd45gtm1Mhol/Gadd45gtm1Mhol
either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ) 		increased cell proliferation J:110650
Gadd45atm1Ajf/Gadd45atm1Ajf
Xpctm1Ecf/Xpctm1Ecf
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6) 		increased lung adenocarcinoma incidence J:101421
increased lung adenoma incidence J:101421
increased lung tumor incidence J:101421
increased metastatic potential J:101421
premature death J:101421
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory