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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tfam
transcription factor A, mitochondrial
MGI:107810
70 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cnptm1(cre)Kan/Cnp+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129X1/SvJ 		abnormal colon morphology J:228933
abnormal enteric neuron morphology J:228933
abnormal PNS glial cell morphology J:228933
abnormal small intestine morphology J:228933
axon degeneration J:228933
decreased body size J:228933
decreased mitochondrial DNA content J:228933
decreased neuron mitochondrial DNA content J:228933
decreased neuron number J:228933
distended abdomen J:228933
neurodegeneration J:228933
postnatal growth retardation J:228933
premature death J:228933
Myl1tm1(cre)Sjb/Myl1+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal respiratory electron transport chain J:81561
bradykinesia J:81561
impaired skeletal muscle contractility J:81561
increased skeletal muscle fiber size J:81561
premature death J:81561
weight loss J:81561
Slc6a3tm1(cre)Lrsn/Slc6a3+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal dopaminergic neuron morphology J:119515
abnormal limb posture J:119515
decreased dopamine level J:119515
decreased exploration in new environment J:119515
decreased locomotor activity J:119515
loss of dopaminergic neurons J:119515
muscle spasm J:119515
neuronal intranuclear inclusions J:119515
premature death J:119515
tremors J:119515
Tfamtm1.1Lrsn/Tfamtm1.1Lrsn
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal heart development J:46387
abnormal mitochondrial ATP synthesis coupled electron transport J:125471
abnormal nervous system physiology J:46387
abnormal somite development J:46387
absent optic nerve J:46387
decreased body size J:46387
decreased mitochondrial DNA content J:46387
disorganized mitochondrial cristae J:46387
embryonic lethality during organogenesis, complete penetrance J:46387
increased apoptosis J:125471
increased mitochondrial size J:46387
Tfamtm1.1Ncdl/Tfamtm1.1Ncdl
Tg(KRT14-cre)1Amc/0
involves: C57BL/6 * CBA 		abnormal hair cycle catagen phase J:213840
abnormal keratinocyte differentiation J:213840
abnormal keratinocyte physiology J:213840
abnormal mitochondrial physiology J:213840
abnormal redox activity J:213840
absent sebaceous gland J:213840
decreased hair follicle number J:213840
decreased subcutaneous adipose tissue amount J:213840
increased keratinocyte proliferation J:213840
premature death J:213840
progressive hair loss J:213840
slow postnatal weight gain J:213840
thick epidermis J:213840
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Camk2a-cre)1Lfr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal respiratory electron transport chain J:72037
axon degeneration J:72037
gliosis J:72037
neurodegeneration J:72037
neuron degeneration J:72037
premature death J:72037
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Ckmm-cre)1Lrsn/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood flow velocity J:51964
abnormal cardiovascular system physiology J:51964
abnormal enzyme/coenzyme level J:125471
abnormal respiratory electron transport chain J:125471
bradykinesia J:51964
dilated cardiomyopathy J:51964
dilated heart left ventricle J:51964
enlarged heart J:51964
increased cardiomyocyte apoptosis J:125471
increased glutathione peroxidase activity J:125471
increased heart weight J:51964
increased physiological sensitivity to xenobiotic J:51964
postnatal growth retardation J:51964
postnatal lethality, complete penetrance J:51964
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal circulating insulin level J:65522
abnormal mitochondrial morphology J:65522
abnormal respiratory electron transport chain J:65522
absent pancreatic beta cells J:65522
decreased insulin secretion J:65522
decreased mitochondrial DNA content J:65522
increased insulin sensitivity J:65522
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal respiratory electron transport chain J:61372
dilated heart atrium J:61372
dilated heart left ventricle J:61372
dilated heart right ventricle J:61372
increased heart weight J:61372
neonatal lethality, incomplete penetrance J:61372
premature death J:61372
Tg(Prm1-Tfam)4Lrsn/?
involves: FVB/N 		normal cellular phenotype J:95207
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11/12/2024
MGI 6.24 		The Jackson Laboratory