Tfam Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tfam
transcription factor A, mitochondrial
MGI:107810

8 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^tm1Lrsn/Gt(ROSA)26Sor⁺ Prkn^tm1Roo/Prkn^tm1Roo Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Tfam^tm1Lrsn/Tfam^tm1Lrsn involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	abnormal axonal transport	J:176022
	abnormal neuron morphology	J:176022
	loss of dopaminergic neurons	J:176022
Gt(ROSA)26Sor^tm1Lrsn/Gt(ROSA)26Sor⁺ Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Tfam^tm1Lrsn/Tfam^tm1Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal locomotor behavior	J:176022
	abnormal mitochondrial physiology	J:176022
	abnormal neuron morphology	J:176022
	loss of dopaminergic neurons	J:176022
	muscle hypertonia	J:176022
	weight loss	J:176022
Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Snca^tm1Nbm/Snca^tm1Nbm Tfam^tm1Lrsn/Tfam^tm1Lrsn involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	neuronal intranuclear inclusions	J:119515

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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