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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsk
cathepsin K
MGI:107823
57 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Not Specified 		normal skeleton phenotype J:194492
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0
involves: C57BL/6 		increased bone mineralization J:194492
increased bone ossification J:194492
increased bone volume J:194492
increased compact bone volume J:194492
increased osteoblast cell number J:194492
increased osteoclast cell number J:194492
increased trabecular bone mass J:194492
increased trabecular bone thickness J:194492
increased trabecular bone volume J:194492
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal osteoblast differentiation J:194492
abnormal osteoblast physiology J:194492
abnormal osteoclast differentiation J:194492
abnormal osteoclast physiology J:194492
increased bone trabecula number J:194492
increased osteoblast cell number J:194492
increased osteoclast cell number J:194492
increased trabecular bone connectivity density J:194492
increased trabecular bone mass J:194492
increased trabecular bone volume J:194492
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: CD-1 		normal skeleton phenotype J:194492
Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp 		abnormal uterus morphology J:211773
decreased prepulse inhibition J:211773
increased bone mineral density J:211773
increased circulating alkaline phosphatase level J:211773
short tibia J:211773
Ctsktm1Mbs/Ctsktm1Mbs
B6.129-Ctsktm1Mbs 		abnormal bone marrow cavity morphology J:128098
abnormal bone remodeling J:128098
abnormal bone structure J:128098
abnormal compact bone morphology J:128098
abnormal long bone diaphysis morphology J:128098
abnormal osteoblast physiology J:128098
abnormal osteoclast physiology J:128098
abnormal trabecular bone morphology J:128098
fragile skeleton J:128098
increased bone trabecula number J:128098
increased compact bone area J:128098
increased osteoclast cell number J:128098
increased trabecular bone mass J:128098
osteopetrosis J:128098
Ctsktm1Psa/Ctsktm1Psa
involves: 129X1/SvJ * C57BL/6J 		abnormal bone structure J:50934
abnormal long bone diaphysis morphology J:50934
abnormal osteoclast physiology J:50934
abnormal trabecular bone morphology J:50934
amyloidosis J:116135
increased long bone epiphyseal plate size J:50934
osteopetrosis J:50934
pulmonary fibrosis J:109717
thick pulmonary interalveolar septum J:109717
Ctsktm1Vuo/Ctsktm1Vuo
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal osteoclast morphology J:95525
abnormal trabecular bone morphology J:95525
increased bone mineral density J:95525
increased osteoclast cell number J:95525
osteopetrosis J:95525
Ctsktm1Ypl/Ctsktm1Ypl
129S4/SvJae-Ctsktm1Ypl 		abnormal alveolar process morphology J:117870
abnormal bone resorption J:117870
abnormal jaw morphology J:117870
abnormal neurocranium morphology J:117870
abnormal phalanx morphology J:117870
abnormal skeleton morphology J:117870
abnormal skeleton physiology J:117870
abnormal tibia morphology J:117870
abnormal tooth development J:117870
absent mandibular angle J:117870
decreased body height J:117870
decreased body weight J:117870
decreased bone volume J:117870
fragile skeleton J:117870
increased diameter of tibia J:117870
increased osteoclast cell number J:117870
increased trabecular bone volume J:117870
large fontanelles J:117870
malocclusion J:117870
osteopetrosis J:117870
postnatal growth retardation J:117870
spondylolysis J:117870
thin neurocranium J:117870
ulcerated autopod J:117870
wide cranial sutures J:117870
Ctsktm1Ypl/Ctsktm1Ypl
B6.129S4-Ctsktm1Ypl 		abnormal skeleton morphology J:117870
normal growth/size/body region phenotype J:117870
increased osteoclast cell number J:117870
osteopetrosis J:117870
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory