About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsk
cathepsin K
MGI:107823
46 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cthrc1tm1.1Suna/Cthrc1tm1.1Suna
Ctsktm1(cre)Ska/Ctsk+
involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj 		abnormal osteoid morphology J:201631
decreased bone mass J:201631
decreased bone ossification J:201631
decreased bone trabecula number J:201631
decreased trabecular bone thickness J:201631
increased bone trabecular spacing J:201631
osteoporosis J:201631
normal skeleton phenotype J:201631
Ctnnb1tm1Mmt/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctsbtm1Jde/Ctsbtm1Jde
Ctsktm1Psa/Ctsktm1Psa
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		abnormal thyroid follicle morphology J:83877
abnormal thyroid follicular cell morphology J:83877
abnormal thyroid hormone level J:83877
Ctsktm1(cre)Ska/Ctsk+
Esr1tm1Mma/Esr1tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal osteoclast physiology J:127179
decreased bone mineral density of femur J:127179
increased bone mineralization J:127179
increased bone ossification J:127179
increased bone resorption J:127179
increased osteoclast cell number J:127179
osteoporosis J:127179
Ctsktm1(cre)Ska/Ctsk+
Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal epiphyseal plate morphology J:224711
abnormal osteoclast physiology J:224711
decreased bone volume J:224711
normal digestive/alimentary phenotype J:224711
failure of tooth eruption J:224711
increased bone mineral density J:224711
osteopetrosis J:224711
postnatal growth retardation J:224711
Ctsktm1(cre)Ska/Ctsk+
Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal lysosome morphology J:236517
abnormal osteoclast morphology J:236517
abnormal osteoclast physiology J:236517
decreased bone mineralization J:236517
decreased bone ossification J:236517
decreased bone resorption J:236517
decreased bone trabecular spacing J:236517
decreased lysosomal enzyme secretion J:236517
decreased osteoblast cell number J:236517
increased bone trabecula number J:236517
increased trabecular bone mass J:236517
increased trabecular bone volume J:236517
Ctsktm1Psa/Ctsktm1Psa
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		abnormal thyroid follicle morphology J:83877
abnormal thyroid gland morphology J:83877
abnormal thyroid hormone level J:83877
decreased circulating thyroxine level J:83877
decreased thyroxine level J:83877
Slc4a2tm2Ges/Slc4a2tm2Ges
Ctsktm1(cre)Ska/Ctsk+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal bone marrow cavity morphology J:193823
abnormal long bone metaphysis morphology J:193823
abnormal long bone morphology J:193823
abnormal osteoclast morphology J:193823
abnormal osteoclast physiology J:193823
abnormal trabecular bone morphology J:193823
increased bone trabecula number J:193823
increased trabecular bone thickness J:193823
increased trabecular bone volume J:193823
osteopetrosis J:193823
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory