Adam8 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adam8
a disintegrin and metallopeptidase domain 8
MGI:107825

12 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adam8^tm1.1Mdz/Adam8^tm1.1Mdz DBA/1LacJ-Adam8^tm1.1Mdz	decreased susceptibility to induced arthritis	J:155243
Adam8^tm1.1Mdz/Adam8^tm1.1Mdz DBA/1LacJ-Adam8^tm1.1Mdz	normal immune system phenotype	J:155243
Adam8^tm1.1Rood/Adam8^tm1.1Rood involves: 129/Sv * C57BL/6 * FVB/N	abnormal osteoclast differentiation	J:172936
	abnormal response/metabolism to endogenous compounds	J:172936
	normal skeleton phenotype	J:172936
Adam8^tm1Bbl/Adam8^tm1Bbl involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:95366
Tg(Acp5-Adam8)#Rood/0 involves: BALB/c * C57BL/6	abnormal osteoclast differentiation	J:172936
	abnormal osteoclast morphology	J:172936
	abnormal trabecular bone morphology	J:172936
	decreased bone mineral density	J:172936
	decreased bone volume	J:172936
	increased bone resorption	J:172936
	increased osteoclast cell number	J:172936

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24