Tubb4a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tubb4a
tubulin, beta 4A class IVA
MGI:107848

33 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ifi208^{Tg(Cspg4-cre)1Akik}/Ifi208⁺ Tubb4a^Jit/Tubb4a^{tm1c(EUCOMM)Hmgu} involves: C57BL/6 * C57BL/6N * FVB/N * SJL	dysmyelination	J:321692
Tubb4a^em1Avan/Tubb4a⁺ involves: C57BL/6	normal behavior/neurological phenotype	J:291062
	decreased myelin sheath thickness	J:291062
	demyelination	J:291062
	dysmyelination	J:291062
Tubb4a^em1Avan/Tubb4a^em1Avan involves: C57BL/6	abnormal axon morphology	J:291062
	abnormal brain development	J:291062
	abnormal cerebellar granule layer morphology	J:291062
	abnormal gait	J:291062
	abnormal myelination	J:291062
	astrocytosis	J:291062
	ataxia	J:291062
	axon degeneration	J:291062
	decreased grip strength	J:291062
	decreased myelin sheath thickness	J:291062
	decreased oligodendrocyte number	J:291062
	demyelination	J:291062
	dysmyelination	J:291062
	dystonia	J:291062
	impaired coordination	J:291062
	impaired righting response	J:291062
	motor developmental delay	J:291062
	neuron degeneration	J:291062
	premature death	J:291062
	tremors	J:291062
	weight loss	J:291062
Tubb4a^Jit/Tubb4a⁺ FVB.B6-Tubb4a^Jit	abnormal cerebellar granule cell morphology	J:321692
	ataxia	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	impaired coordination	J:321692
Tubb4a^Jit/Tubb4a^Jit FVB.B6-Tubb4a^Jit	abnormal cerebellar granule cell morphology	J:321692
	abnormal cerebellum morphology	J:321692
	abnormal nervous system tract morphology	J:321692
	abnormal oligodendrocyte physiology	J:321692
	ataxia	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	increased neuron apoptosis	J:321692
	neuron degeneration	J:321692
	premature death	J:321692
	thin cerebellar granule layer	J:321692
	thin cerebellar molecular layer	J:321692
Tubb4a^Jit/Tubb4a^{tm1(KOMP)Wtsi} involves: C57BL/6 * C57BL/6N * FVB/N	abnormal cerebellar granule cell morphology	J:321692
	abnormal motor capabilities/coordination/movement	J:321692
	abnormal nervous system tract morphology	J:321692
	cerebellum atrophy	J:321692
	dysmyelination	J:321692
	premature death	J:321692
Tubb4a^Jit/Tubb4a^{tm1c(EUCOMM)Hmgu} Tg(Atoh1-cre)1Bfri/0 involves: C57BL/6 * C57BL/6N * CBA * FVB/N	abnormal cerebellar granule cell morphology	J:321692
Tubb4a^{tm1(KOMP)Wtsi}/Tubb4a^{tm1(KOMP)Wtsi} involves: C57BL/6N * FVB/N	normal behavior/neurological phenotype	J:321692
	normal mortality/aging	J:321692
Tubb4a^{tm1.1(KOMP)Wtsi}/Tubb4a^{tm1.1(KOMP)Wtsi} C57BL/6N-Tubb4a^{tm1.1(KOMP)Wtsi}/J	decreased fasting circulating glucose level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24