About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926
35 phenotypes from 6 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		decreased body size J:186058
decreased body weight J:186058
decreased eye anterior chamber depth J:186058
lethality, incomplete penetrance J:186058
ocular hypotension J:186058
retina degeneration J:186058
retina neovascularization J:186058
Rock2tm1.1Itl/Rock2+
Tg(Tagln-cre)1Her/0
B6.Cg-Rock2tm1.1Itl Tg(Tagln-cre)1Her 		abnormal cytokine secretion J:222206
abnormal vascular smooth muscle physiology J:222206
decreased susceptibility to hypertension J:222206
decreased vascular smooth muscle cell proliferation J:222206
Rock2tm1.1Itl/Rock2tm1.1Itl
Tg(Tagln-cre)1Her/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL 		embryonic lethality, complete penetrance J:222206
Rock2tm1.1Liao/Rock2+
involves: C57BL/6 		normal cardiovascular system phenotype J:135152
Rock2tm1Sna/Rock2tm1Sna
involves: 129X1/SvJ * C57BL/6 		abnormal extraembryonic tissue morphology J:84386
abnormal placenta morphology J:84386
decreased body size J:84386
hemorrhage J:84386
premature death J:84386
prenatal lethality, incomplete penetrance J:84386
Rock2tm1Zpj/Rock2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal cardiovascular system morphology J:224630
abnormal cardiovascular system physiology J:224630
abnormal circulating cholesterol level J:224630
decreased circulating free fatty acids level J:224630
decreased susceptibility to diet-induced obesity J:224630
normal growth/size/body region phenotype J:224630
normal homeostasis/metabolism phenotype J:224630
improved glucose tolerance J:224630
Rock2tm1Zpj/Rock2tm1Zpj
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal actin cytoskeleton morphology J:225274
abnormal excitatory postsynaptic potential J:225274
abnormal synapse morphology J:225274
decreased paired-pulse facilitation J:225274
increased dendritic spine length J:225274
normal nervous system phenotype J:225274
reduced long-term potentiation J:225274
Rock2tm2Liao/Rock2tm2Liao
Tg(Myh6-cre)2182Mds/?
involves: 129/Sv * C57BL/6 		abnormal heart morphology J:196433
abnormal heart size J:196433
normal cardiovascular system phenotype J:196433
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory