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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926
35 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
involves: 129S5/SvEvBrd * C57BL/6J
decreased body size J:186058
decreased body weight J:186058
decreased eye anterior chamber depth J:186058
lethality, incomplete penetrance J:186058
ocular hypotension J:186058
retina degeneration J:186058
retina neovascularization J:186058
Rock2tm1.1Itl/Rock2+
Tg(Tagln-cre)1Her/0
B6.Cg-Rock2tm1.1Itl Tg(Tagln-cre)1Her
abnormal cytokine secretion J:222206
abnormal vascular smooth muscle physiology J:222206
decreased susceptibility to hypertension J:222206
decreased vascular smooth muscle cell proliferation J:222206
Rock2tm1.1Itl/Rock2tm1.1Itl
Tg(Tagln-cre)1Her/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
embryonic lethality, complete penetrance J:222206
Rock2tm1.1Liao/Rock2+
involves: C57BL/6
normal cardiovascular system phenotype J:135152
Rock2tm1Sna/Rock2tm1Sna
involves: 129X1/SvJ * C57BL/6
abnormal extraembryonic tissue morphology J:84386
abnormal placenta morphology J:84386
decreased body size J:84386
hemorrhage J:84386
premature death J:84386
prenatal lethality, incomplete penetrance J:84386
Rock2tm1Zpj/Rock2+
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal cardiovascular system morphology J:224630
abnormal cardiovascular system physiology J:224630
abnormal circulating cholesterol level J:224630
decreased circulating free fatty acids level J:224630
decreased susceptibility to diet-induced obesity J:224630
normal growth/size/body region phenotype J:224630
normal homeostasis/metabolism phenotype J:224630
improved glucose tolerance J:224630
Rock2tm1Zpj/Rock2tm1Zpj
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal actin cytoskeleton morphology J:225274
abnormal excitatory postsynaptic potential J:225274
abnormal synapse morphology J:225274
decreased paired-pulse facilitation J:225274
increased dendritic spine length J:225274
normal nervous system phenotype J:225274
reduced long-term potentiation J:225274
Rock2tm2Liao/Rock2tm2Liao
Tg(Myh6-cre)2182Mds/?
involves: 129/Sv * C57BL/6
abnormal heart morphology J:196433
abnormal heart size J:196433
normal cardiovascular system phenotype J:196433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory