Rock1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927

38 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rock1^tm1.1Itl/Rock1^tm1.1Itl involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	normal growth/size/body region phenotype	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	increased body weight	J:204885
	increased food intake	J:204885
	increased total body fat amount	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Not Specified	abnormal autophagy	J:207251
Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺ involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	increased body weight	J:204885
	increased epididymal fat pad weight	J:204885
	increased mesenteric fat pad weight	J:204885
	increased renal fat pad weight	J:204885
	increased total body fat amount	J:204885
	obese	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	abnormal nervous system electrophysiology	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Pomc1-cre)16Lowl/0 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	decreased locomotor activity	J:204885
	increased body weight	J:204885
	increased circulating insulin level	J:204885
	increased circulating leptin level	J:204885
	increased epididymal fat pad weight	J:204885
	increased food intake	J:204885
	increased mesenteric fat pad weight	J:204885
	increased renal fat pad weight	J:204885
	increased total body fat amount	J:204885
	insulin resistance	J:204885
	normal skeleton phenotype	J:204885
Rock1^tm1.2Itl/Rock1^tm1.2Itl Not Specified	abnormal autophagy	J:207251
Rock1^{tm1b(NCOM)Mfgc}/Rock1^{tm1b(NCOM)Mfgc} C57BL/6N-Rock1^{tm1b(NCOM)Mfgc}/Tcp	edema	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Rock1^tm1Leiw/Rock1⁺ FVB.129S7-Rock1^tm1Leiw	embryonic lethality at implantation, incomplete penetrance	J:111469
Rock1^tm1Leiw/Rock1^tm1Leiw FVB.129S7-Rock1^tm1Leiw	abnormal cardiovascular system physiology	J:111469
	embryonic lethality at implantation, incomplete penetrance	J:111469
	increased heart rate	J:111469
Rock1^tm1Lex/Rock1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	lethality, incomplete penetrance	J:186058
	ocular hypotension	J:186058
	premature death	J:186058
	normal vision/eye phenotype	J:186058
Rock1^tm1Liao/Rock1⁺ C57BL/6-Rock1^tm1Liao	abnormal leukocyte adhesion	J:135152
	abnormal leukocyte migration	J:135152
	abnormal respiratory system physiology	J:112242
	abnormal vascular endothelial cell physiology	J:135152
	abnormal vascular smooth muscle morphology	J:135152
	abnormal vascular wound healing	J:135152
	impaired macrophage chemotaxis	J:135152
	impaired neutrophil recruitment	J:135152
Rock1^tm1Sna/Rock1^tm1Sna B6N.129X1-Rock1^tm1Sna	abnormal eyelid morphology	J:98250
	abnormal keratinocyte morphology	J:98250
	blepharitis	J:98250
	eyelids open at birth	J:98250
	omphalocele	J:98250
	postnatal lethality, incomplete penetrance	J:98250

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24