Sqstm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sqstm1
sequestosome 1
MGI:107931

70 phenotypes from 10 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sqstm1^em1Kmts/Sqstm1⁺ involves: C57BL/6N	abnormal forestomach morphology	J:342766
	enlarged liver	J:342766
	esophagus hyperplasia	J:342766
	hyperkeratosis	J:342766
	hypoglycemia	J:342766
	increased blood urea nitrogen level	J:342766
	increased circulating aspartate transaminase level	J:342766
	increased circulating cholesterol level	J:342766
	increased circulating creatinine level	J:342766
	postnatal growth retardation	J:342766
Sqstm1^em2Kmts/Sqstm1^em2Kmts involves: C57BL/6N	normal growth/size/body region phenotype	J:342766
Sqstm1^em2Kmts/Sqstm1^em2Kmts involves: C57BL/6N	normal reproductive system phenotype	J:342766
Sqstm1^tm1.1Ewa/Sqstm1^tm1.1Ewa Tg(Nes-cre)1Kag/0 involves: C57BL/6J	increased abdominal adipose tissue amount	J:201732
	increased body weight	J:201732
	increased food intake	J:201732
Sqstm1^tm1.1Sral/Sqstm1⁺ involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal bone structure	J:173755
	abnormal osteoclast differentiation	J:173755
	increased osteoclast cell number	J:173755
Sqstm1^tm1.1Sral/Sqstm1^tm1.1Sral involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal bone mineralization	J:173755
	abnormal bone ossification	J:173755
	abnormal bone structure	J:173755
	abnormal compact bone morphology	J:173755
	abnormal osteoclast differentiation	J:173755
	abnormal osteoclast morphology	J:173755
	abnormal trabecular bone morphology	J:173755
	increased osteoclast cell number	J:173755
Sqstm1^{tm1a(KOMP)Wtsi}/Sqstm1^{tm1a(KOMP)Wtsi} B6JTyr;B6N-Sqstm1^{tm1a(KOMP)Wtsi}/Wtsi	abnormal behavior	J:175295
	decreased circulating glucose level	J:175295
	decreased mean corpuscular hemoglobin	J:175295
	increased body length	J:175295
Sqstm1^tm1Hwl/Sqstm1^tm1Hwl B6.129P2-Sqstm1^tm1Hwl	abnormal mitochondrial physiology	J:181228
	abnormal respiratory electron transport chain	J:181228
	decreased oxygen consumption	J:181228
	decreased subcutaneous adipose tissue amount	J:181228
	lordokyphosis	J:181228
	oxidative stress	J:181228
	premature aging	J:181228
	premature death	J:181228
	rough coat	J:181228
Sqstm1^tm1Jjw/Sqstm1^tm1Jjw involves: 129 * C57BL/6	abnormal osteoclast differentiation	J:141179
	abnormal osteoclast physiology	J:141179
	normal skeleton phenotype	J:141179
Sqstm1^tm1Jmos/Sqstm1^tm1Jmos involves: 129S1/Sv * 129X1/SvJ	abnormal aerobic respiration	J:194291
Sqstm1^tm1Jmos/Sqstm1^tm1Jmos involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal osteoclast differentiation	J:90010
	decreased interleukin-6 secretion	J:90010
	decreased osteoclast cell number	J:90010
Sqstm1^tm1Keta/Sqstm1^tm1Keta B6.129-Sqstm1^tm1Keta	impaired glucose tolerance	J:201732
	increased body weight	J:201732
	increased circulating leptin level	J:201732
	increased food intake	J:201732
	increased neuron number	J:201732
Sqstm1^tm1Keta/Sqstm1^tm1Keta involves: 129	hyperglycemia	J:130839
Sqstm1^tm1Keta/Sqstm1^tm1Keta involves: 129	increased susceptibility to age related obesity	J:130839
Sqstm1^tm1Keta/Sqstm1^tm1Keta involves: 129 * C57BL/6N	abnormal bone remodeling	J:264183
	abnormal bone structure	J:264183
	abnormal osteoblast physiology	J:264183
	abnormal osteoclast differentiation	J:264183
	abnormal osteoclast physiology	J:264183
	abnormal trabecular bone morphology	J:264183
	decreased bone trabecular spacing	J:264183
	increased bone mineral density of femur	J:264183
	increased bone trabecula number	J:264183
	increased bone volume	J:264183
	obese	J:264183
Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd	normal cellular phenotype	J:194291
	normal growth/size/body region phenotype	J:194291
	normal homeostasis/metabolism phenotype	J:194291
Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * DBA	normal behavior/neurological phenotype	J:194291
	normal growth/size/body region phenotype	J:194291
	normal homeostasis/metabolism phenotype	J:194291
	normal liver/biliary system phenotype	J:194291
Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Tg(Fabp4-cre)1Rev/0 Not Specified	abnormal brown adipose tissue thermogenesis	J:194291
	abnormal mitochondrial ATP synthesis coupled electron transport	J:194291
	abnormal mitochondrial crista morphology	J:194291
	normal behavior/neurological phenotype	J:194291
	decreased core body temperature	J:194291
	decreased energy expenditure	J:194291
	decreased locomotor activity	J:194291
	disorganized mitochondrial cristae	J:194291
	hepatic steatosis	J:194291
	impaired glucose tolerance	J:194291
	increased body weight	J:194291
	increased brown fat cell lipid droplet size	J:194291
	increased lean body mass	J:194291
	increased total body fat amount	J:194291
	increased white fat cell size	J:194291
	insulin resistance	J:194291
Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Tg(Nes-cre)1Kln/0 involves: C57BL/6 * DBA	normal behavior/neurological phenotype	J:194291
	normal growth/size/body region phenotype	J:194291

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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