Tfb2m Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tfb2m
transcription factor B2, mitochondrial
MGI:107937

17 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Tfb2m^{tm1a(KOMP)Wtsi}/Tfb2m⁺ Tg(Ins2-cre)23Herr/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal mitochondrial ATP synthesis coupled electron transport	J:256448
	abnormal mitochondrial physiology	J:256448
	decreased circulating insulin level	J:256448
	decreased insulin secretion	J:256448
	decreased pancreatic beta cell mass	J:256448
	decreased pancreatic islet number	J:256448
	impaired glucose tolerance	J:256448
Tfb2m^{tm1a(KOMP)Wtsi}/Tfb2m^{tm1a(KOMP)Wtsi} Tg(Ins2-cre)23Herr/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal mitochondrial morphology	J:256448
	abnormal mitochondrial physiology	J:256448
	abnormal mitophagy	J:256448
	abnormal pancreatic beta cell morphology	J:256448
	abnormal pancreatic islet cell apoptosis	J:256448
	decreased circulating insulin level	J:256448
	decreased insulin secretion	J:256448
	decreased mitochondrial DNA content	J:256448
	decreased pancreatic beta cell mass	J:256448
	decreased pancreatic islet number	J:256448
	dilated mitochondrion	J:256448
	hyperglycemia	J:256448
	impaired autophagy	J:256448
	increased circulating glucose level	J:256448
	increased endoplasmic reticulum stress	J:256448

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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