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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
MGI:107940
79 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:199122
increased germinal center B cell number J:199122
increased spleen germinal center number J:199122
increased spleen germinal center size J:199122
normal neoplasm J:199122
Ezh2em1Jbn/Ezh2+
C57BL/6J-Ezh2em1Jbn 		increased body weight J:267184
increased growth rate J:267184
increased heart weight J:267184
increased kidney weight J:267184
increased spleen weight J:267184
Ezh2em1Jbn/Ezh2em1Jbn
C57BL/6J-Ezh2em1Jbn 		decreased embryo size J:267184
perinatal lethality, complete penetrance J:267184
primary atelectasis J:267184
Ezh2em1Jiaf/Ezh2+
C57BL/6J-Ezh2em1Jiaf 		abnormal osteoblast physiology J:345603
normal growth/size/body region phenotype J:345603
increased body weight J:345603
increased femur compact bone thickness J:345603
increased internal diameter of femur J:345603
normal mortality/aging J:345603
normal skeleton phenotype J:345603
Ezh2em1Jiaf/Ezh2em1Jiaf
C57BL/6J-Ezh2em1Jiaf 		lethality throughout fetal growth and development, complete penetrance J:345603
Ezh2tm1.1Nesh/Ezh2+
Cd19tm1(cre)Cgn/Cd19+
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal spleen morphology J:239472
abnormal spleen white pulp morphology J:239472
enlarged lymph nodes J:239472
enlarged spleen J:239472
increased B cell derived lymphoma incidence J:239472
increased leukemia incidence J:239472
premature death J:239472
Ezh2tm1.1Nesh/Ezh2tm1.1Nesh
Cd19tm1(cre)Cgn/Cd19+
involves: 129 * 129P2/OlaHsd * C57BL/6 		enlarged lymph nodes J:239472
enlarged spleen J:239472
increased B cell derived lymphoma incidence J:239472
Ezh2tm1.1Sho/Ezh2tm1.1Sho
involves: 129 * C57BL/6J 		embryonic growth arrest J:134477
embryonic lethality between implantation and somite formation, complete penetrance J:134477
failure to gastrulate J:134477
Ezh2tm1.1Tara/Ezh2tm1.1Tara
involves: 129P2/OlaHsd 		prenatal lethality, complete penetrance J:83216
Ezh2tm1a(EUCOMM)Wtsi/Ezh2+
C57BL/6N-Ezh2tm1a(EUCOMM)Wtsi/Wtsi 		increased circulating triglyceride level J:175295
increased mean corpuscular hemoglobin J:175295
increased sacral vertebrae number J:175295
Ezh2tm1Jnw/Ezh2tm1Jnw
involves: 129P2/OlaHsd 		abnormal embryonic tissue morphology J:69977
abnormal extraembryonic tissue morphology J:69977
absent inner cell mass proliferation J:69977
embryonic growth retardation J:69977
embryonic lethality, complete penetrance J:69977
failure to gastrulate J:69977
Ezh2tm1Tara/Ezh2tm1Tara
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:83216
Ezh2tm1Tara/Ezh2tm1Tara
Cd19tm1(cre)Cgn/?
involves: 129P2/OlaHsd 		normal immune system phenotype J:83216
Ezh2tm1Tara/Ezh2tm1Tara
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd 		decreased B cell proliferation J:199122
decreased germinal center B cell number J:199122
decreased IgG1 level J:199122
decreased IgG2b level J:199122
decreased IgG3 level J:199122
decreased spleen germinal center number J:199122
decreased spleen germinal center size J:199122
normal immune system phenotype J:199122
Ezh2tm1Tara/Ezh2tm1Tara
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		normal behavior/neurological phenotype J:155739
Ezh2tm1Tara/Ezh2tm1Tara
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal B cell differentiation J:83216
abnormal immunoglobulin V(D)J recombination J:83216
abnormal pro-B cell morphology J:83216
decreased immature B cell number J:83216
decreased pre-B cell number J:83216
Ezh2tm1Yugo/Ezh2tm1Yugo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S/Sv * C57BL/6 		abnormal neuron differentiation J:154927
Ezh2tm1Yugo/Ezh2tm1Yugo
Tg(Nes-cre/ERT2)5-1Imayo/0
involves: C57BL/6 		abnormal neuron differentiation J:154927
Ezh2tm2.1Sho/Ezh2tm2.1Sho
involves: 129S1/Sv * CD-1 		embryonic growth retardation J:142193
embryonic lethality between somite formation and embryo turning, complete penetrance J:142193
Ezh2tm2Sho/Ezh2tm2.1Sho
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		decreased double-positive T cell number J:182211
decreased thymocyte number J:182211
enlarged lymph nodes J:182211
enlarged spleen J:182211
increased double-negative T cell number J:182211
increased leukemia incidence J:182211
Ezh2tm2Sho/Ezh2tm2Sho
involves: 129S1/Sv * 129S7/SvEvBrd 		myocardial ventricular hypertrabeculation J:179371
perinatal lethality, complete penetrance J:179371
thin myocardium compact layer J:179371
Ezh2tm2Sho/Ezh2tm2Sho
Olig1tm1(cre)Rth/0
involves: 129S1/Sv * 129S4/SvJae 		abnormal oligodendrocyte morphology J:256017
dysmyelination J:256017
Ezh2tm2Sho/Ezh2tm2Sho
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal endometrial gland morphology J:290765
abnormal endometrium morphology J:290765
abnormal parturition J:290765
abnormal uterine epithelium development J:290765
decreased litter size J:290765
decreased uterine NK cell number J:290765
dystocia J:290765
endometrium hyperplasia J:290765
enlarged uterine horn J:290765
increased endometrial gland number J:290765
reduced female fertility J:290765
Ezh2tm2Sho/Ezh2tm2Sho
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		decreased double-positive T cell number J:182211
decreased thymocyte number J:182211
enlarged lymph nodes J:182211
enlarged spleen J:182211
increased double-negative T cell number J:182211
increased leukemia incidence J:182211
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte 		abnormal mammary gland development J:202724
abnormal mammary gland duct morphology J:202724
decreased body size J:202724
decreased mammary gland epithelial cell proliferation J:202724
impaired mammary gland growth during pregnancy J:202724
prenatal lethality, complete penetrance J:202724
small lymph nodes J:202724
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
involves: C57BL/6 * FVB 		abnormal mammary gland development J:202724
prenatal lethality, complete penetrance J:202724
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte 		abnormal mammary gland development J:202724
abnormal mammary gland duct morphology J:202724
decreased body size J:202724
decreased mammary gland epithelial cell proliferation J:202724
impaired mammary gland growth during pregnancy J:202724
prenatal lethality, complete penetrance J:202724
small lymph nodes J:202724
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
involves: C57BL/6 * FVB 		abnormal mammary gland development J:202724
prenatal lethality, complete penetrance J:202724
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory