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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
MGI:107956
61 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Slc8a1tm1Kdp/Slc8a1tm1Kdp
involves: 129S4/SvJae 		abnormal myocardial fiber physiology J:101484
decreased cardiac muscle contractility J:101484
enlarged heart J:101484
pregnancy-related premature death J:101484
premature death J:101484
Slc8a1m51207Hubr/Slc8a1m51207Hubr
involves: C57BL/6 * FVB/N 		abnormal cardiovascular system physiology J:167034
abnormal heart tube morphology J:167034
abnormal pharyngeal arch morphology J:167034
absent heartbeat J:167034
absent placenta hemotrichorial membrane J:167034
absent placental labyrinth J:167034
absent vitelline blood vessels J:167034
edema J:167034, J:173681
embryonic lethality during organogenesis, complete penetrance J:167034
enlarged first pharyngeal arch J:167034
Slc8a1tm1Herc/Slc8a1+
involves: 129 * CD-1 		abnormal exocrine pancreas physiology J:186743
abnormal glucose homeostasis J:186743
abnormal pancreas physiology J:186743
increased insulin secretion J:186743
increased pancreatic beta cell mass J:186743
increased pancreatic beta cell proliferation J:186743
Slc8a1tm1Herc/Slc8a1tm1Herc
involves: 129 * CD-1 		embryonic lethality, complete penetrance J:186743
Slc8a1tm1Hssh/Slc8a1tm1Hssh
involves: 129S4/SvJae * C3H * C57BL/6 		abnormal myocardium layer morphology J:106177
abnormal placenta vasculature J:106177
abnormal visceral yolk sac morphology J:106177
abnormal vitelline vascular remodeling J:106177
absent placental labyrinth J:106177
decreased heart rate J:106177
distended pericardium J:106177
embryonic growth arrest J:106177
embryonic lethality during organogenesis, complete penetrance J:106177
Slc8a1tm1Hssh/Slc8a1tm1Hssh
involves: 129S4/SvJae * C57BL/6J 		abnormal endocardium morphology J:74096
abnormal heart atrium morphology J:74096
abnormal heart development J:74096
absent atrioventricular cushions J:74096
decreased heart rate J:74096
distended pericardium J:74096
embryo tissue necrosis J:74096
embryonic growth arrest J:74096
embryonic lethality during organogenesis, complete penetrance J:74096
thin ventricular wall J:74096
trabecula carnea hypoplasia J:74096
Slc8a1tm1Sjc/Slc8a1tm1Sjc
involves: 129X1/SvJ * C57BL/6 		abnormal cardiovascular system physiology J:69362
abnormal heart morphology J:69362
abnormal visceral yolk sac morphology J:69362
abnormal vitelline vasculature morphology J:69362
absent atrioventricular cushions J:69362
absent heartbeat J:69362
absent vitelline blood vessels J:69362
decreased embryo size J:69362
embryonic growth retardation J:69362
embryonic lethality during organogenesis, complete penetrance J:69362
fetal cardiomyocyte disarray J:69362
increased embryonic tissue cell apoptosis J:69362
poor circulation J:69362
Slc8a1tm1Yin/Slc8a1+
involves: 129X1/SvJ * C57BL/6J 		abnormal cardiac muscle relaxation J:75050
abnormal cardiovascular system physiology J:65985
cardiac interstitial fibrosis J:75050
heart left ventricle hypertrophy J:75050
impaired smooth muscle contractility J:65985
increased heart left ventricle muscle contractility J:75050
increased left ventricle diastolic pressure J:75050
increased left ventricle systolic pressure J:75050
Slc8a1tm1Yin/Slc8a1tm1Yin
involves: 129X1/SvJ * C57BL/6J 		abnormal cardiovascular system physiology J:65985
abnormal fetal cardiomyocyte mitochondrial morphology J:102564
abnormal fetal cardiomyocyte morphology J:65985
abnormal mitochondrial crista morphology J:102564
abnormal mitochondrial matrix morphology J:102564
abnormal mitochondrial shape J:102564
abnormal vitelline vascular remodeling J:65985
abnormal vitelline vasculature morphology J:65985
absent heartbeat J:65985
absent vitelline blood vessels J:65985
absent Z line J:102564
decreased embryo size J:65985
decreased fetal cardiomyocyte number J:65985
dilated mitochondrion J:102564
embryonic lethality during organogenesis, complete penetrance J:65985
enlarged pericardium J:65985
fetal cardiomyocyte disarray J:102564
increased cardiomyocyte apoptosis J:65985
irregular heartbeat J:65985
poor circulation J:65985
thin ventricular wall J:65985
Slc8a1tm2Kdp/Slc8a1tm2Kdp
involves: 129S4/SvJae * Black Swiss 		abnormal cardiovascular system physiology J:102710, J:103484
abnormal fetal cardiomyocyte morphology J:102710
embryonic lethality during organogenesis, complete penetrance J:103484
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory