Myd88 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Myd88
myeloid differentiation primary response gene 88
MGI:108005

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Arih2^tm1Mak/Arih2^tm1Mak Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal survival	J:191066
Clec7a^tm1Yiw/Clec7a^tm1Yiw Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd * BALB/cA * C57BL/6J	abnormal cytokine secretion	J:116670
	abnormal dendritic cell physiology	J:116670
Fadd^tm1Mpa/Fadd^tm1Mpa Myd88^tm1Aki/Myd88^tm1Aki Tg(Vil1-cre)997Gum/0 B6.Cg-Fadd^tm1Mpa Myd88^tm1Aki Tg(Vil1-cre)997Gum	cecum inflammation	J:175865
	decreased Paneth cell number	J:175865
	normal digestive/alimentary phenotype	J:175865
Ifna6^tm1Aki/Ifna6⁺ Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd	abnormal plasmacytoid dendritic cell morphology	J:124340
	decreased interferon-alpha secretion	J:124340
Ifnar1^tm1Agt/Ifnar1^tm1Agt Myd88^tm1Aki/Myd88⁺ B6.129-Myd88^tm1Aki Ifnar1^tm1Agt	increased susceptibility to parasitic infection	J:140485
Ifnar1^tm1Agt/Ifnar1^tm1Agt Myd88^tm1Aki/Myd88^tm1Aki B6.129-Myd88^tm1Aki Ifnar1^tm1Agt	increased susceptibility to parasitic infection	J:140485
	increased susceptibility to parasitic infection induced morbidity/mortality	J:140485
Ifnar1^tm1Agt/Ifnar1^tm1Agt Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd * 129S2/SvPas	abnormal leukocyte migration	J:171379
Igh-J^{tm1(Ighel)Cys}/Igh-J^{tm1(Ighel)Cys} Myd88^tm1Aki/Myd88^tm1Aki Igkj1^{tm1(IgkHyHEL10)Mnz}/0 involves: 129P2/OlaHsd	increased IgM level	J:115059
Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	normal immune system phenotype	J:200745
	normal renal/urinary system phenotype	J:200745
Myd88^poc/Myd88^poc Ptpn6^m1Btlr/Ptpn6^m1Btlr C57BL/6J-Ptpn6^m1Btlr Myd88^poc	normal immune system phenotype	J:142845
Myd88^tm1Aki/Myd88^tm1Aki Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2	normal integument phenotype	J:312394
Myd88^tm1Aki/Myd88^tm1Aki Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:221901
Myd88^tm1Aki/Myd88^tm1Aki Tank^tm1Aki/Tank^tm1Aki involves: 129/Sv * 129P2/OlaHsd * C57BL/6	increased anti-double stranded DNA antibody level	J:151757
Myd88^tm1Aki/Myd88^tm1Aki Tg(IghelMD4)4Ccg/0 Tg(KLK4mHEL)6Ccg/0 involves: 129P2/OlaHsd * C57BL/6	decreased mature B cell number	J:115059
	increased B-1 B cell number	J:115059
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1⁺ B6.129P2-Myd88^tm1Aki Ticam1^tm1Aki	decreased macrophage cytokine production	J:140485
	decreased macrophage nitric oxide production	J:140485
	increased susceptibility to parasitic infection	J:140485
	increased susceptibility to parasitic infection induced morbidity/mortality	J:140485
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki B6.129P2-Myd88^tm1Aki Ticam1^tm1Aki	decreased macrophage cytokine production	J:140485
	decreased macrophage nitric oxide production	J:140485
	increased susceptibility to parasitic infection	J:140485
	increased susceptibility to parasitic infection induced morbidity/mortality	J:140485
Myd88^tm1Aki/Myd88^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki involves: 129P2/OlaHsd	abnormal dendritic cell physiology	J:174941
	abnormal macrophage physiology	J:174941
Myd88^tm1Aki/Myd88^tm1Aki Tnfaip3^tm1.1Gvl/Tnfaip3^tm1.1Gvl Tg(Vil1-cre)997Gum/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	increased enterocyte apoptosis	J:163410
	increased susceptibility to induced colitis	J:163410
Myd88^tm1Aki/Myd88^tm1Aki Tnip1^tm1.1Pcoh/Tnip1^tm1.1Pcoh involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:176826
Myd88^tm1Aki/Myd88^tm1Aki Tradd^tm1.1Mpa/Tradd^tm1.1Mpa involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	decreased circulating tumor necrosis factor level	J:139030
Myd88^tm1Aki/Myd88^tm1Aki Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy involves: 129P2/OlaHsd * C57BL/6	normal hematopoietic system phenotype	J:174308
Myd88^tm1Defr/Myd88^tm1Defr Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA	normal hematopoietic system phenotype	J:205446
	normal immune system phenotype	J:205446
Ticam1^Lps2/Ticam1^Lps2 Myd88^tm1Aki/Myd88^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage physiology	J:84896
	decreased tumor necrosis factor secretion	J:84896

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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