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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nkx3-2
NK3 homeobox 2
MGI:108015
75 phenotypes from 7 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nkx3-2tm1(cre)Wez/Nkx3-2tm1(cre)Wez
involves: 129S7/SvEvBrd * C57BL/6 		abnormal skeleton morphology J:148724
abnormal vertebral column morphology J:148724
absent basioccipital bone J:148724
absent basisphenoid bone J:148724
Nkx3-2tm1.1Tlu/Nkx3-2tm1.1Tlu
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal basioccipital bone morphology J:55583
abnormal basisphenoid bone morphology J:55583
abnormal bone ossification J:55583
abnormal cartilage development J:55583
abnormal cervical atlas morphology J:55583
abnormal cranium morphology J:55583
abnormal intervertebral disk morphology J:55583
abnormal neurocranium morphology J:55583
abnormal thoracic cavity morphology J:55583
abnormal vertebrae morphology J:55583
abnormal vertebral arch morphology J:55583
abnormal vertebral body development J:55583
abnormal vertebral body morphology J:55583
absent spleen J:55583
absent supraoccipital bone J:55583
axial skeleton hypoplasia J:55583
barrel chest J:55583
decreased body height J:55583
normal limbs/digits/tail phenotype J:55583
neonatal lethality, complete penetrance J:55583
short tail J:55583
short vertebral column J:55583
small exoccipital bone J:55583
small vertebrae J:55583
Nkx3-2tm1Bobh/Nkx3-2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal malleus morphology J:88584
abnormal middle ear morphology J:88584
abnormal middle ear ossicle morphology J:88584
gonial bone hypoplasia J:88584
kinked tail J:57112
Nkx3-2tm1Bobh/Nkx3-2tm1Bobh
involves: 129P2/OlaHsd * C57BL/6 		abnormal axial skeleton morphology J:57112
abnormal basicranium morphology J:57112
abnormal cartilage development J:79198
abnormal cartilage morphology J:79198
abnormal cervical vertebrae morphology J:57112
abnormal digestive organ placement J:93234
abnormal left-right axis patterning J:93234
abnormal malleus morphology J:88584
abnormal middle ear ossicle morphology J:88584
abnormal notochord morphology J:57112
abnormal pancreas development J:93234
abnormal rib morphology J:57112
abnormal sclerotome morphology J:57112
abnormal thoracic vertebrae morphology J:57112
abnormal tympanic ring morphology J:88584
abnormal vertebrae morphology J:57112
abnormal vertebral arch development J:57112
absent gonial bone J:88584
absent intervertebral disk J:57112
absent spleen J:57112
absent vertebral body J:57112
basioccipital bone hypoplasia J:57112
decreased body height J:57112
kinked tail J:79198
neonatal lethality, complete penetrance J:79198, J:93802
perinatal lethality, complete penetrance J:57112
short tail J:57112
small basioccipital bone J:57112
small basisphenoid bone J:57112
small caudal vertebrae J:57112
thick tail J:57112
tympanic ring hypoplasia J:88584
vertebral compression J:57112
Nkx3-2tm1Tlu/Nkx3-2+
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal vertebrae morphology J:55583
Nkx3-2tm1Tlu/Nkx3-2tm1Tlu
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal basioccipital bone morphology J:55583
abnormal basisphenoid bone morphology J:55583
abnormal bone ossification J:55583
abnormal cartilage development J:55583
abnormal cranium morphology J:55583
abnormal intervertebral disk morphology J:55583
abnormal neurocranium morphology J:55583
abnormal thoracic cavity morphology J:55583
abnormal vertebrae morphology J:55583
abnormal vertebral arch morphology J:55583
abnormal vertebral body development J:55583
abnormal vertebral body morphology J:55583
absent arcus anterior J:55583
absent spleen J:55583
absent supraoccipital bone J:55583
axial skeleton hypoplasia J:55583
barrel chest J:55583
decreased body height J:55583
normal limbs/digits/tail phenotype J:55583
neonatal lethality, complete penetrance J:55583
short tail J:55583
short vertebral column J:55583
small exoccipital bone J:55583
small vertebrae J:55583
Nkx3-2tm1Tno/Nkx3-2tm1Tno
involves: 129S4/SvJae * C57BL/6J 		abnormal axial skeleton morphology J:77612
abnormal cartilage development J:77612
abnormal cervical atlas morphology J:77612
abnormal cervical axis morphology J:77612
abnormal cervical vertebrae morphology J:77612
abnormal craniofacial bone morphology J:77612
abnormal digestive system morphology J:77612
abnormal exoccipital bone morphology J:77612
abnormal hyoid bone body morphology J:77612
abnormal lumbar vertebrae morphology J:77612
abnormal notochord morphology J:77612
abnormal odontoid process morphology J:77612
abnormal sclerotome morphology J:77612
abnormal supraoccipital bone morphology J:77612
abnormal thoracic vertebrae morphology J:77612
abnormal vertebrae development J:77612
abnormal vertebral arch morphology J:77612
abnormal vertebral body morphology J:77612
absent intervertebral disk J:77612
absent spleen J:77612
absent ventral tubercle of atlas J:77612
basioccipital bone hypoplasia J:77612
basisphenoid bone hypoplasia J:77612
decreased body length J:77612
decreased cell proliferation J:77612
kinked tail J:77612
neonatal lethality, complete penetrance J:77612
persistence of notochord tissue J:77612
respiratory distress J:77612
vertebral body hypoplasia J:77612
Nkx3-2tm3.1(cre)Tlu/Nkx3-2tm3.1(cre)Tlu
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:178893
Nkx3-2tm4.1(cre)Tlu/Nkx3-2tm4.1(cre)Tlu
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:178893
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory