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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pkn1
protein kinase N1
MGI:108022
36 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pkn1tm1Ajmc/Pkn1tm1Ajmc
B6.129P2-Pkn1tm1Ajmc 		abnormal calcium ion homeostasis J:258572
abnormal cardiovascular system physiology J:258572
abnormal heart echocardiography feature J:258572
decreased cardiac muscle contractility J:258572
decreased cardiac muscle relaxation J:258572
decreased left ventricle developed pressure J:258572
decreased left ventricle systolic pressure J:258572
increased myocardial infarct size J:258572
normal mortality/aging J:229595
normal reproductive system phenotype J:229595
Pkn1tm1b(KOMP)Wtsi/Pkn1tm1b(KOMP)Wtsi
C57BL/6N-Pkn1tm1b(KOMP)Wtsi/H 		decreased fasting circulating glucose level J:211773
decreased large unstained cell number J:211773
decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
decreased monocyte cell number J:211773
decreased neutrophil cell number J:211773
decreased red blood cell distribution width J:211773
increased hemoglobin content J:211773
increased total body fat amount J:211773
Pkn1tm1Kik/Pkn1tm1Kik
B6.129P2-Pkn1tm1Kik 		abnormal germinal center B cell physiology J:193187
abnormal somatic hypermutation frequency J:193187
decreased activation-induced B cell apoptosis J:193187
glomerulonephritis J:193187
normal immune system phenotype J:193187
increased anti-double stranded DNA antibody level J:193187
increased B cell proliferation J:193187
increased germinal center B cell number J:193187
increased IgG1 level J:193187
increased IgG2a level J:193187
increased IgG2b level J:193187
increased IgM level J:193187
increased mesangial cell number J:193187
increased renal glomerulus basement membrane thickness J:193187
increased spleen germinal center size J:193187
increased splenocyte number J:193187
renal glomerular immunoglobulin deposits J:193187
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory