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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atr
ataxia telangiectasia and Rad3 related
MGI:108028
114 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atrtm1.1Twgl/Atrtm1.1Twgl
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL 		no abnormal phenotype detected J:150723
Atrtm1Akl/Atr+
involves: 129P2/OlaHsd * C57BL/6 		normal neoplasm J:61732
Atrtm1Akl/Atrtm1Akl
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:61732
Atrtm1b(KOMP)Wtsi/Atr+
B6N(Cg)-Atrtm1b(KOMP)Wtsi/2J 		abnormal spinal cord morphology J:211773
decreased circulating glucose level J:211773
increased fasting circulating glucose level J:211773
increased heart weight J:211773
Atrtm1b(KOMP)Wtsi/Atrtm1b(KOMP)Wtsi
B6N(Cg)-Atrtm1b(KOMP)Wtsi/2J 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Atrtm1Bal/Atr+
involves: 129 * C57BL/6 		increased tumor incidence J:60768
premature death J:60768
Atrtm1Bal/Atrtm1Bal
involves: 129 * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:60768
Atrtm1Bal/Atrtm2Bal
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		abnormal coat/hair pigmentation J:123200
abnormal hair cycle J:123200
abnormal hair follicle development J:123200
abnormal hair follicle morphology J:123200
abnormal hair growth J:123200
abnormal hair shaft morphology J:123200
abnormal intestinal epithelium morphology J:123200
abnormal liver morphology J:123200
abnormal thymus involution J:123200
abnormal trabecular bone morphology J:123200
alopecia J:123200
cardiac fibrosis J:123200
decreased body weight J:123200
decreased cell proliferation J:123200
decreased compact bone thickness J:123200
decreased hair follicle number J:123200
decreased subcutaneous adipose tissue amount J:123200
decreased thymocyte number J:123200
delayed hair regrowth J:123200
kidney atrophy J:123200
kidney inflammation J:123200
kyphosis J:123200
osteoporosis J:123200
renal fibrosis J:123200
renal glomerulus atrophy J:123200
renal tubule atrophy J:123200
sebaceous gland hyperplasia J:123200
thick skin J:123200
Atrtm1Bal/Atrtm2Bal
Tg(Syn1-cre)671Jxm/0
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CBA 		normal behavior/neurological phenotype J:123200
Atrtm1Ofc/Atrtm1Ofc
involves: 129 * C57BL/6 		abnormal female meiosis J:307570
abnormal ovarian follicle morphology J:307570
decreased granulosa cell proliferation J:307570
decreased primary ovarian follicle number J:307570
decreased secondary ovarian follicle number J:307570
impaired ovarian folliculogenesis J:307570
increased granulosa cell apoptosis J:307570
increased granulosa cell proliferation J:307570
increased primordial ovarian follicle number J:307570
Atrtm1Ofc/Atrtm1Ofc
Not Specified 		abnormal astrocyte morphology J:151542
abnormal bone marrow morphology J:151542
abnormal brain morphology J:151542
abnormal cell cycle J:151542
abnormal coat/hair pigmentation J:151542
abnormal cranial suture morphology J:151542
abnormal DNA replication J:151542
abnormal fontanelle morphology J:151542
abnormal head shape J:151542
abnormal head size J:151542
abnormal hematopoietic stem cell morphology J:151542
abnormal nose morphology J:151542
abnormal oogenesis J:151542
abnormal placenta morphology J:151542
abnormal primary ovarian follicle morphology J:151542
absent corpus callosum J:151542
absent oocytes J:151542
cachexia J:151542
decreased body length J:151542
decreased body weight J:151542
decreased bone marrow cell number J:151542
decreased brain size J:151542
decreased brain weight J:151542
decreased hair follicle number J:151542
decreased liver weight J:151542
decreased lung weight J:151542
decreased ovary weight J:151542
decreased spleen weight J:151542
decreased testis weight J:151542
decreased thymus weight J:151542
early cellular replicative senescence J:151542
increased apoptosis J:151542
increased cellular sensitivity to methylmethanesulfonate J:151542
increased cellular sensitivity to ultraviolet irradiation J:151542
increased fibroblast apoptosis J:151542
kyphosis J:151542
malocclusion J:151542
microcephaly J:151542
micrognathia J:151542
osteoporosis J:151542
pancytopenia J:151542
premature aging J:151542
premature death J:151542
prenatal lethality, incomplete penetrance J:151542
proportional dwarf J:151542
sloping forehead J:151542
small thoracic cavity J:151542
spontaneous chromosome breakage J:151542
thin epidermis J:151542
Atrtm1Twgl/Atr+
involves: 129S6/SvEvTac * C57BL/6J 		decreased mitotic index J:150723
induced chromosome breakage J:150723
Atrtm1Twgl/Atrtm1Twgl
involves: 129S6/SvEvTac * C57BL/6J 		decreased mitotic index J:150723
induced chromosome breakage J:150723
Atrtm2Bal/Atrtm2Bal
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J 		abnormal cerebral cortex morphology J:181920
abnormal corpus callosum morphology J:181920
abnormal stratification in cerebral cortex J:181920
hippocampus hypoplasia J:181920
Atrtm2Bal/Atrtm2Bal
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal neuron proliferation J:181920
Atrtm2Bal/Atrtm2Bal
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal cerebellar granule layer morphology J:181920
abnormal cerebellum development J:181920
abnormal cerebral cortex morphology J:181920
abnormal corpus callosum morphology J:181920
abnormal embryonic/fetal subventricular zone morphology J:181920
abnormal neuron proliferation J:181920
abnormal olfactory bulb granule cell layer morphology J:181920
abnormal rhombic lip morphology J:181920
decreased body size J:181920
decreased brain size J:181920
decreased cerebellar granule cell number J:181920
decreased cerebellar granule cell precursor proliferation J:181920
ectopic Purkinje cell J:181920
increased neuron apoptosis J:181920
postnatal growth retardation J:181920
postnatal lethality, complete penetrance J:181920
Atrtm2Ofc/Atrtm2Ofc
Not Specified 		normal craniofacial phenotype J:151542
normal growth/size/body region phenotype J:151542
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory