Traf3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Traf3
TNF receptor-associated factor 3
MGI:108041

45 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Traf3^tm1Rbr/Traf3^tm1Rbr involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal B cell physiology	J:132877
	increased follicular B cell number	J:132877
	increased marginal zone B cell number	J:132877
	lymph node hyperplasia	J:132877
Tg(Lck-cre)I57Jxm/? Traf3^tm1Rbr/Traf3^tm1Rbr involves: C57BL/6 * ICR * SJL	abnormal T cell physiology	J:132877
	decreased CD4-positive, alpha-beta T cell number	J:132877
	decreased CD8-positive, alpha-beta T cell number	J:132877
Traf3^m1Btlr/Traf3^m1Btlr C57BL/6J-Traf3^m1Btlr	decreased mature B cell number	J:212064
Traf3^m1Btlr/Traf3^m1Btlr C57BL/6J-Traf3^m1Btlr	impaired humoral immune response	J:212064
Traf3^m2Btlr/Traf3^m2Btlr C57BL/6J-Traf3^m2Btlr	decreased IgG level	J:217797
Traf3^m2Btlr/Traf3^m2Btlr C57BL/6J-Traf3^m2Btlr	decreased response to antigen	J:217797
Traf3^tm1Bal/Traf3^tm1Bal involves: 129S4/SvJae * C57BL/6J	abnormal B cell differentiation	J:37065
	abnormal T cell physiology	J:37065
	decreased body size	J:37065
	decreased body weight	J:37065
	decreased double-positive T cell number	J:37065
	decreased leukocyte cell number	J:37065
	decreased thymocyte number	J:37065
	hypoglycemia	J:37065
	increased circulating corticosterone level	J:37065
	postnatal lethality, complete penetrance	J:37065
	spleen hypoplasia	J:37065
Traf3^tm1Bshp/Traf3^tm1Bshp Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	abnormal adaptive immunity	J:124329
	abnormal immune system organ morphology	J:124329
	abnormal immune system physiology	J:124329
	abnormal kidney morphology	J:124329
	abnormal leukocyte morphology	J:124329
	abnormal liver morphology	J:124329
	abnormal lymph node B cell domain morphology	J:124329
	abnormal spleen germinal center morphology	J:124329
	autoimmune response	J:124329
	decreased B cell apoptosis	J:124329
	decreased physiological sensitivity to xenobiotic	J:124329
	decreased T cell number	J:124329
	enlarged lymph nodes	J:124329
	enlarged spleen	J:124329
	increased anti-double stranded DNA antibody level	J:124329
	increased B cell number	J:124329
	increased follicular B cell number	J:124329
	increased IgA level	J:124329
	increased IgG2a level	J:124329
	increased IgG2b level	J:124329
	increased IgG3 level	J:124329
	increased IgG level	J:124329
	increased IgM level	J:124329
	increased marginal zone B cell number	J:124329
	increased spleen white pulp amount	J:124329
	increased transitional stage B cell number	J:124329

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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