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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smad2
SMAD family member 2
MGI:108051
73 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cumulus expansion J:142827
abnormal ovarian follicle morphology J:142827
decreased litter size J:142827
decreased oocyte number J:142827
decreased tertiary ovarian follicle number J:142827
increased atretic ovarian follicle number J:142827
increased circulating follicle stimulating hormone level J:142827
increased circulating luteinizing hormone level J:142827
premature ovarian failure J:142827
reduced female fertility J:142827
Apctm1Mmt/Apc+
Smad2tm1Kato/Smad2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J 		decreased tumor-free survival time J:79668
increased intestinal adenoma incidence J:79668
Apctm1Mmt/Apc+
Smad2tm2Kato/Smad2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J 		decreased tumor-free survival time J:79668
increased intestinal adenoma incidence J:79668
M1665Asr/M1665Asr+
Smad2tm1Cxd/Smad2+
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J 		increased body weight J:141536
increased bone mineral density J:141536
increased lean body mass J:141536
M2195Asr/M2195Asr+
Smad2tm1Cxd/Smad2+
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J 		decreased body weight J:141536
decreased bone mass J:141536
decreased bone mineral content J:141536
Nodaltm1Rob/Nodal+
Smad2tm1.1Epb/Smad2+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL 		abnormal eye development J:183402
abnormal olfactory epithelium morphology J:183402
embryonic growth retardation J:183402
holoprosencephaly J:183402
proboscis J:183402
Ppm1atm1.1Xya/Ppm1atm1.1Xya
Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0
involves: 129S6/SvEvTac * FVB/N 		abnormal wound healing J:178733
enhanced wound healing J:178733
increased keratinocyte migration J:178733
Smad2tm1.1Epb/Smad2tm1.1Epb
Smad3tm1Cxd/Smad3tm1Cxd
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal cell morphology J:119642
decreased apoptosis J:119642
premature death J:119642
Smad2tm1.1Epb/Smad2tm1.1Epb
Smad3tm1Cxd/Smad3tm1Cxd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL 		abnormal cell morphology J:119642
abnormal cell physiology J:119642
increased physiological sensitivity to xenobiotic J:119642
normal liver/biliary system phenotype J:119642
Smad2tm1Cxd/Smad2+
Smad3tm1Cxd/Smad3+
involves: 129S6/SvEvTac * C57BL/6 		abnormal Meckel's cartilage morphology J:76396
Smad2tm1Cxd/Smad2+
Smad3tm1Cxd/Smad3+
involves: 129S6/SvEvTac * NIH Black Swiss 		abnormal craniofacial morphology J:70388, J:106308
abnormal developmental patterning J:106308
abnormal endoderm development J:106308
abnormal foregut morphology J:106308
abnormal gastrulation J:106308
abnormal heart looping J:106308
abnormal hepatic cord morphology J:70388
abnormal hepatoblast migration J:106308
abnormal hepatocyte physiology J:70388
abnormal liver morphology J:70388
abnormal pericardial cavity morphology J:106308
abnormal somite development J:106308
cyclopia J:106308
decreased hepatocyte proliferation J:70388
delayed hepatic development J:106308
dilated liver sinusoidal space J:70388
embryonic growth retardation J:106308
embryonic lethality during organogenesis, incomplete penetrance J:70388
holoprosencephaly J:106308
increased erythrocyte cell number J:70388
increased fetal size J:70388
lethality throughout fetal growth and development, complete penetrance J:106308
liver hypoplasia J:70388, J:106308
small liver J:70388
small thyroid gland J:106308
Smad2tm1Enl/Smad2+
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S4/SvJae 		abnormal craniofacial morphology J:48467
abnormal direction of embryo turning J:48467
abnormal gastrulation J:48467
abnormal heart looping J:48467
abnormal lateral plate mesoderm morphology J:48467
abnormal left-right axis patterning J:48467
cyclopia J:48467
right pulmonary isomerism J:48467
rostral body truncation J:48467
transposition of great arteries J:48467
Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1 		abnormal heart development J:84300
absent foregut J:84300
fused somites J:84300
rostral body truncation J:84300
Smad2tm3Rob/Smad2tm3Rob
Smad3tm1Xfw/Smad3tm1Xfw
involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR 		osteoarthritis J:95374
Smad2tm4(SMADH3)Rob/Smad2tm4(SMADH3)Rob
involves: 129S/SvEv * C57BL/6 * ICR 		abnormal forebrain development J:95374
abnormal hindbrain development J:95374
exencephaly J:95374
holoprosencephaly J:95374
microcephaly J:95374
neonatal lethality, incomplete penetrance J:95374
prenatal lethality, incomplete penetrance J:95374
Smad2tm5(SMAD2)Rob/Smad2tm5(SMAD2)Rob
involves: 129S/SvEv 		embryonic lethality, complete penetrance J:82809
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory