Nkx2-1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx2-1
NK2 homeobox 1
MGI:108067

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Foxe1^tm1Rdl/Foxe1^tm1Rdl Nkx2-1^tm1Rdl/Nkx2-1⁺ B6.129-Foxe1^tm1Rdl Nkx2-1^tm1Rdl	normal endocrine/exocrine gland phenotype	J:95017
Gata6^tm1Msp/Gata6⁺ Nkx2-1^tm1Shk/Nkx2-1⁺ involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1	abnormal lung development	J:117072
	abnormal lung epithelium morphology	J:117072
	abnormal lung saccule morphology	J:117072
	abnormal pulmonary alveolus epithelium morphology	J:117072
	absent alveolar lamellar bodies	J:117072
	decreased surfactant secretion	J:117072
	postnatal lethality, incomplete penetrance	J:117072
	thick lung-associated mesenchyme	J:117072

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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