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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Traf6
TNF receptor-associated factor 6
MGI:108072
94 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Traf6tm1.1Mpa/Traf6tm1.1Mpa
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		decreased circulating interleukin-6 level J:145306
decreased susceptibility to injury J:145306
Traf6tm1Jino/Traf6tm1Jino
involves: 129P2/OlaHsd * C57BL/6 		abnormal coat/ hair morphology J:77350
abnormal hair follicle development J:77350
abnormal male preputial gland morphology J:77350
abnormal Meibomian gland development J:77350
abnormal osteoclast differentiation J:77453
abnormal sebaceous gland morphology J:77350
abnormal skin pigmentation J:77350
absent eccrine glands J:77350
absent guard hair J:77350
alopecia J:77350
decreased body size J:77453
decreased body weight J:77453
decreased immature B cell number J:77453
decreased lymph node number J:77453
failure of tooth eruption J:77453
kinked tail J:77350
osteopetrosis J:77453
postnatal growth retardation J:77453
postnatal lethality, complete penetrance J:77453
preweaning lethality, incomplete penetrance J:77453
small perianal sebaceous gland J:77350
translucent skin J:77350
Traf6tm1Mak/Traf6tm1Mak
involves: 129P3/J 		abnormal long bone metaphysis morphology J:54467
abnormal long bone morphology J:54467
abnormal macrophage physiology J:54467
abnormal osteoclast morphology J:54467
abnormal osteoclast physiology J:54467
absent incisors J:54467
absent molars J:54467
decreased B cell proliferation J:54467
decreased body length J:54467
decreased body weight J:54467
decreased bone resorption J:54467
decreased circulating phosphate level J:54467
decreased length of long bones J:54467
decreased survivor rate J:54467
decreased tumor necrosis factor secretion J:54467
enlarged heart J:54467
enlarged liver J:54467
enlarged spleen J:54467
failure of tooth eruption J:54467
hypochromic anemia J:54467
increased bone mineral density J:54467
osteopetrosis J:54467
perinatal lethality, incomplete penetrance J:54467
postnatal lethality, incomplete penetrance J:54467
short femur J:54467
Traf6tm1Ywc/Traf6tm1Ywc
Not Specified 		abnormal dendritic cell differentiation J:85808
abnormal dendritic cell physiology J:85808
abnormal lymph node morphology J:85808
abnormal spleen morphology J:85808
absent spleen white pulp J:85808
decreased body size J:85808
decreased dendritic cell number J:85808
decreased interleukin-6 secretion J:85808
decreased interleukin-12 secretion J:85808
enlarged spleen J:85808
osteopetrosis J:85808
postnatal lethality, complete penetrance J:85808
thymus atrophy J:85808
Traf6tm2a(EUCOMM)Wtsi/Traf6+
C57BL/6N-Traf6tm2a(EUCOMM)Wtsi/Wtsi 		increased grip strength J:211773
Traf6tm2a(EUCOMM)Wtsi/Traf6tm2a(EUCOMM)Wtsi
C57BL/6N-Traf6tm2a(EUCOMM)Wtsi/Wtsi 		abnormal brain commissure morphology J:239583
abnormal brain morphology J:239583
abnormal coronary sinus connection J:239583
abnormal ductus venosus valve topology J:239583
abnormal endolymphatic sac topology J:239583
abnormal eye muscle morphology J:239583
abnormal forebrain morphology J:239583
abnormal kidney morphology J:239583
abnormal Mullerian duct morphology J:239583
abnormal myocardium compact layer morphology J:239583
abnormal olfactory bulb morphology J:239583
abnormal optic cup morphology J:239583
abnormal optic stalk morphology J:239583
abnormal stapes morphology J:239583
abnormal vertebral artery topology J:239583
abnormal vitelline vein topology J:239583
abnormal Wolffian duct morphology J:239583
absent ductus venosus valve J:239583
absent stapedial artery J:239583
bifid ureter J:239583
blood in lymph vessels J:239583
dilated bile duct J:239583
ductus venosus stenosis J:239583
exencephaly J:239583
herniated liver J:239583
intestinal/bowel diverticulum J:239583
multiple persisting craniopharyngeal ducts J:239583
muscular ventricular septal defect J:239583
perimembraneous ventricular septal defect J:239583
persistent right 6th pharyngeal arch artery J:239583
persistent right dorsal aorta J:239583
preweaning lethality, complete penetrance J:211773
subcutaneous edema J:239583
thin hypoglossal nerve J:239583
umbilical vein stenosis J:239583
Traf6tm2Ywc/Traf6tm2Ywc
Tg(Cd4-cre)1Cwi/?
involves: C57BL/6 * DBA/2 		abnormal lymphocyte anergy J:130882
increased activated T cell number J:130882
increased memory T cell number J:130882
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory