Smo Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smo
smoothened, frizzled class receptor
MGI:108075

54 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Smo^tm1Amc/Smo^tm1Amc involves: 129X1/SvJ * C57BL/6 * C57BL/6N	abnormal embryonic neuroepithelial layer differentiation	J:297055
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:297055
Atoh1^tm3Hzo/Atoh1⁺ Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} involves: 129 * 129S7/SvEvBrd * 129X1/SvJ	abnormal cerebellum external granule cell layer morphology	J:155047
	abnormal cerebellum morphology	J:155047
	abnormal neuronal precursor proliferation	J:155047
	irregular external granule cell layer thickness	J:155047
Atoh1^tm3Hzo/Atoh1^tm1Hzo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} involves: 129 * 129S7/SvEvBrd * 129X1/SvJ	abnormal neuronal precursor proliferation	J:155047
	cerebellum atrophy	J:155047
	thin external granule cell layer	J:155047
Bmp4^tm2Blh/Bmp4⁺ Smo^tm1Amc/Smo^tm1Amc involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	absent vitelline blood vessels	J:128367
Cdcp1^tm1.2Moas/Cdcp1^tm1.2Moas Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺ Tg(KRT14-cre/ERT)20Efu/0 involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL	abnormal skin condition	J:194368
	abnormal skin morphology	J:194368
	focal hair loss	J:194368
	hunched posture	J:194368
	increased tumor growth/size	J:194368
	increased tumor incidence	J:194368
	premature death	J:194368
	thick epidermis	J:194368
	thick skin	J:194368
Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Smo^tm1Amc/Smo^tm1Amc involves: 129S7/SvEvBrd * 129X1/SvJ * FVB/N	abnormal neuronal precursor cell number	J:243907
En1^tm2(cre)Wrst/? Gli3^tm1Alj/Gli3^tm1Alj Smo^tm2Amc/Smo^tm2Amc involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal cerebellar foliation	J:137136
	abnormal cerebellum morphology	J:137136
	abnormal hindbrain morphology	J:137136
	abnormal rhombomere morphology	J:137136
	abnormal tectum morphology	J:137136
	enlarged cerebral aqueduct	J:137136
	enlarged tectum	J:137136
	normal nervous system phenotype	J:137136
	small cerebellum	J:137136
	thin external granule cell layer	J:137136
Gli3^tm1Alj/Gli3^tm1Alj Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^tm2Amc/Smo^tm2Amc involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	abnormal digestive system morphology	J:199664
Gpr161^tm1Lex/Gpr161^tm1Lex Smo^tm1Amc/Smo^tm1Amc involves: 129S/SvEv * 129X1/SvJ * C57BL/6N	abnormal craniofacial morphology	J:193395
	abnormal neural tube morphology	J:193395
	normal growth/size/body region phenotype	J:193395
Gt(ROSA)26Sor^{tm1(Gli2)Jmao}/Gt(ROSA)26Sor⁺ Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	normal digestive/alimentary phenotype	J:199664
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺ Hk2^tm1.1Uku/Hk2⁺ Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	increased medulloblastoma incidence	J:210113
	premature death	J:210113
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺ Hk2^tm1.1Uku/Hk2^tm1.1Uku Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	abnormal neuronal precursor proliferation	J:210113
	abnormal tumor vascularization	J:210113
	decreased tumor growth/size	J:210113
	increased medulloblastoma incidence	J:210113
	increased tumor latency	J:210113
	premature death	J:210113
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm2(EGFP/cre)Alj} Pgbd5^tm1.1Aken/Pgbd5^tm1.1Aken involves: 129 * C57BL/6J * C57BL/6NTac * SW	increased medulloblastoma incidence	J:346387
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/? Smo^tm2Amc/Smo^tm2Amc Tg(Tagln-cre)1Jjl/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	normal cardiovascular system phenotype	J:204743
Gt(ROSA)26Sor^tm6Dym/? Smo^tm2Amc/Smo^tm2Amc Sox9^tm3(cre)Crm/Sox9⁺ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal temporomandibular joint morphology	J:153743
	small mandibular condyloid process	J:153743
Ift122^sopb/Ift122^sopb Smo^tm1Amc/Smo^tm1Amc involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J	abnormal neural tube morphology	J:168317
Ift172^wim/Ift172^wim Smo^bnb/Smo^bnb involves: C57BL/6J	abnormal direction of heart looping	J:100466
	decreased motor neuron number	J:100466
	embryonic lethality during organogenesis, complete penetrance	J:100466
	open neural tube	J:100466
Kif7^maki/Kif7^maki Smo^bnb/Smo^bnb Tg(Hlxb9-GFP)1Tmj/? involves: C57BL/6J * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:151965
	normal nervous system phenotype	J:151965
Kif7^tm1.2Hui/Kif7^tm1.2Hui Smo^tm1Amc/Smo^tm1Amc involves: 129S6/SvEvTac * 129X1/SvJ * CD-1	abnormal neural tube morphology	J:152259
	abnormal neuron differentiation	J:152259
	absent neuronal precursor cells	J:152259
	normal embryo phenotype	J:152259
	exencephaly	J:152259
Mir34a^tm1.2Arte/Mir34a⁺ Tg(Neurod2-SmoA1)199Jols/0 involves: C57BL/6 C57BL/6N	increased medulloblastoma incidence	J:221990
Mir34a^tm1.2Arte/Mir34a^tm1.2Arte Tg(Neurod2-SmoA1)199Jols/0 involves: C57BL/6 C57BL/6N	increased medulloblastoma incidence	J:221990
Smo^bnb/Smo^bnb Tmem107^schlei/Tmem107^schlei involves: C3HeB/FeJ * C57BL/6J	abnormal floor plate morphology	J:186552
	exencephaly	J:186552
Smo^tm1Amc/Smo^tm1Amc Tulp3^hhkr/Tulp3^hhkr involves: 129X1/SvJ * C3H/HeH * C57BL/6	abnormal neural tube morphology	J:147584
	increased spinal cord size	J:147584
	pericardial edema	J:147584
Smo^tm1Amc/Smo^tm1Amc Wdpcp^cys40/Wdpcp^cys40 involves: 129X1/SvJ * C57BL/6J	abnormal embryo development	J:205269
Smo^tm2Amc/Smo^tm2.1Amc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J	decreased cardiac neural crest cell number	J:135134
	impaired cardiac neural crest cell differentiation	J:135134
Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Smo^tm1Amc/Smo^tm1Amc involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	increased forebrain size	J:103820

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