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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcnq1
potassium voltage-gated channel, subfamily Q, member 1
MGI:108083
75 phenotypes from 9 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kcnq1m1Anu/?
involves: BALB/c * C57BL/6 * DBA/2 		abnormal motor capabilities/coordination/movement J:196547
circling J:196547
head tossing J:196547
jerky movement J:196547
opisthotonus J:196547
tremors J:196547
Kcnq1tm1Apf/Kcnq1tm1Apf
involves: 129P2/OlaHsd * C57BL/6 		abnormal basilar membrane morphology J:110797
abnormal crista ampullaris morphology J:110797
abnormal gastric chief cell morphology J:66428
abnormal gastric parietal cell morphology J:66428
abnormal inner ear vestibule morphology J:66428
abnormal mucous neck cell morphology J:66428
abnormal otolith morphology J:110797
abnormal semicircular canal morphology J:66428
abnormal stria vascularis morphology J:110797
abnormal tectorial membrane morphology J:110797
abnormal vestibular labyrinth morphology J:110797
absent cochlear hair cells J:66428, J:110797
absent organ of Corti supporting cells J:66428, J:110797
absent vestibular hair cell stereocilia J:110797
absent vestibular hair cells J:110797
normal cardiovascular system phenotype J:66428
circling J:66428, J:110797
cochlear ganglion degeneration J:110797
collapsed Reissner membrane J:66428, J:110797
deafness J:110797
detached otolithic membrane J:66428, J:110797
dilated gastric gland J:66428
enlarged stomach J:66428
head bobbing J:66428, J:110797
hyperactivity J:66428, J:110797
hypochlorhydria J:66428
increased circulating gastrin level J:66428
increased or absent threshold for auditory brainstem response J:110797
increased stomach mucosa thickness J:66428
increased stomach pH J:66428
organ of Corti degeneration J:66428, J:110797
small scala media J:66428, J:110797
spinning J:110797
stereotypic behavior J:66428
stomach mucosa hyperplasia J:66428
thin stria vascularis J:110797
utricular macular degeneration J:110797
Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cochlear sensory epithelium morphology J:67873
abnormal crista ampullaris neuroepithelium morphology J:67873
abnormal heart electrocardiography waveform feature J:67873
abnormal inner ear canal morphology J:67873
abnormal inner ear morphology J:67873
abnormal P wave J:67873
abnormal T wave J:67873
abnormal utricle morphology J:67873
abnormal vestibular saccule morphology J:67873
absent pinna reflex J:67873
bidirectional circling J:67873
cardiac hypertrophy J:67873
cochlear inner hair cell degeneration J:67873
cochlear outer hair cell degeneration J:67873
collapsed Reissner membrane J:67873
deafness J:67873
head bobbing J:67873
hyperactivity J:67873
impaired righting response J:67873
increased heart weight J:67873
prolonged PR interval J:67873
prolonged QRS complex duration J:67873
prolonged QT interval J:67873
syndromic hearing impairment J:67873
Kcnq1tm2Kpfe/Kcnq1tm2Kpfe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal membranous labyrinth morphology J:93197
abnormal T wave J:93197
absent distortion product otoacoustic emissions J:93197
absent pinna reflex J:93197
bidirectional circling J:93197
cochlear inner hair cell degeneration J:93197
cochlear outer hair cell degeneration J:93197
collapsed Reissner membrane J:93197
deafness J:93197
decreased body weight J:93197
head bobbing J:93197
hyperactivity J:93197
impaired coordination J:93197
impaired swimming J:93197
increased or absent threshold for auditory brainstem response J:93197
increased QRS amplitude J:93197
prolonged QT interval J:93197
syndromic hearing impairment J:93197
Kcnq1tm3Kpfe/Kcnq1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		prolonged QT interval J:93197
Kcnq1tm3Kpfe/Kcnq1tm3Kpfe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		normal behavior/neurological phenotype J:93197
normal hearing/vestibular/ear phenotype J:93197
prolonged QT interval J:93197
Kcnq1tm4Kpfe/Kcnq1tm4Kpfe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		no abnormal phenotype detected J:93197
Kcnq1vtg-2J/Kcnq1vtg-2J
C3H/HeJCrl-Kcnq1vtg-2J/J 		circling J:79858
deafness J:79858
head tossing J:79858
Kcnq1vtg-3J/Kcnq1vtg-3J
C57BL/6J-Kcnq1vtg-3J/J 		abnormal cochlea morphology J:87349
abnormal gait J:87349
abnormal inner ear vestibule morphology J:87349
abnormal otolith morphology J:87349
circling J:87349
head tossing J:87349
impaired balance J:87349
retropulsion J:87349
tremors J:87349
Kcnq1vtg-4J/Kcnq1vtg-4J
B6.NOD-Kcnq1vtg-4J/J 		bidirectional circling J:112553
deafness J:112553
head tossing J:112553
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory