Cep250 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cep250
centrosomal protein 250
MGI:108084

26 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cep250^em1Glvr/Cep250^em1Glvr C57BL/6-Cep250^em1Glvr	abnormal centrosome morphology	J:324876
	arrest of male meiosis	J:324876
	azoospermia	J:324876
	increased male germ cell apoptosis	J:324876
	male infertility	J:324876
	normal reproductive system phenotype	J:324876
	small testis	J:324876
Cep250^{tm1a(EUCOMM)Wtsi}/Cep250^{tm1a(EUCOMM)Wtsi} C57BL/6N-Cep250^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal auditory brainstem response	J:211773
	absent pinna reflex	J:211773
	increased total body fat amount	J:211773
	male infertility	J:211773
Cep250^{tm1a(EUCOMM)Wtsi}/Cep250^{tm1a(EUCOMM)Wtsi} Tg(Stra8-icre)1Reb/0 involves: C57BL/6N	abnormal seminiferous tubule morphology	J:326549
	decreased male germ cell number	J:326549
	small seminiferous tubules	J:326549
	small testis	J:326549
Cep250^{tm1b(EUCOMM)Wtsi}/Cep250^{tm1b(EUCOMM)Wtsi} involves: C57BL/6N	abnormal centrosome morphology	J:326549
	abnormal male meiosis	J:326549
	abnormal seminiferous tubule morphology	J:326549
	azoospermia	J:326549
	decreased male germ cell number	J:326549
	decreased oocyte number	J:326549
	decreased ovary weight	J:326549
	male infertility	J:326549
	reduced female fertility	J:326549
	small seminiferous tubules	J:326549
	small testis	J:326549
Cep250^tm1Jzb/Cep250^tm1Jzb involves: C57BL/6	abnormal electroretinogram waveform feature	J:276510
	abnormal retina blood vessel morphology	J:276510
	abnormal retina outer nuclear layer morphology	J:276510
	decreased a-wave amplitude	J:276510
	decreased b-wave amplitude	J:276510
	decreased total retina thickness	J:276510
	retina degeneration	J:276510
	retina photoreceptor degeneration	J:276510
	thin retina outer nuclear layer	J:276510

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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