Hdac1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hdac1
histone deacetylase 1
MGI:108086

54 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac1^MommeD5/Hdac1^MommeD5 FVB/NJ-Hdac1^MommeD5	embryonic growth arrest	J:142335
	embryonic growth retardation	J:142335
	prenatal lethality, complete penetrance	J:142335
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129 * C57BL/6 * CBA	no abnormal phenotype detected	J:150709
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Tg(KRT14-cre)1Ipc/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal coat appearance	J:205733
	abnormal epidermal layer morphology	J:205733
	abnormal epidermis stratum basale morphology	J:205733
	abnormal eyelid morphology	J:205733
	abnormal hair follicle development	J:205733
	abnormal hair follicle morphology	J:205733
	abnormal hair follicle orientation	J:205733
	abnormal hair medulla	J:205733
	abnormal hair shaft morphology	J:205733
	abnormal keratinocyte differentiation	J:205733
	abnormal keratinocyte morphology	J:205733
	abnormal nail color	J:205733
	abnormal nail matrix morphology	J:205733
	abnormal nail morphology	J:205733
	abnormal periorbital region morphology	J:205733
	abnormal sebaceous gland morphology	J:205733
	abnormal tail morphology	J:205733
	abnormal vibrissa morphology	J:205733
	abnormal zigzag hair morphology	J:205733
	alopecia	J:205733
	decreased body size	J:205733
	dilated hair follicle infundibulum	J:205733
	distorted hair follicle pattern	J:205733
	ectopic melanocytes	J:205733
	epidermal hyperplasia	J:205733
	epithelioid cyst	J:205733
	hyperkeratosis	J:205733
	increased foot pad pigmentation	J:205733
	increased tail pigmentation	J:205733
	Meibomian gland hyperplasia	J:205733
	narrow eye opening	J:205733
	short hair	J:205733
	short vibrissae	J:205733
	thick epidermis	J:205733
	thin epidermis stratum granulosum	J:205733
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Tg(Myh6-cre)2182Mds/? involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	no abnormal phenotype detected	J:123173
Hdac1^tm1.1Mrl/Hdac1^tm1.1Mrl Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	normal hematopoietic system phenotype	J:197818
	normal liver/biliary system phenotype	J:197818
Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased cell proliferation	J:157903
Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	normal immune system phenotype	J:194769
Hdac1^tm1.2Eno/Hdac1^tm1.2Eno involves: 129S/SvEv * C57BL/6 * CD-1	embryonic lethality, complete penetrance	J:123173
Hdac1^tm1.2Pmt/Hdac1^tm1.2Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal cell cycle	J:157903
	embryonic lethality, complete penetrance	J:157903
Hdac1^{tm1b(EUCOMM)Wtsi}/Hdac1⁺ C57BL/6N-Hdac1^{tm1b(EUCOMM)Wtsi}/Ieg	cardiovascular system phenotype	J:211773
	decreased exploration in new environment	J:211773
	decreased heart rate variability	J:211773
	decreased mean corpuscular hemoglobin	J:211773
Hdac1^{tm1b(EUCOMM)Wtsi}/Hdac1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Hdac1^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Hdac1^tm1Sei/Hdac1⁺ either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	prenatal lethality, incomplete penetrance	J:76941
Hdac1^tm1Sei/Hdac1^tm1Sei either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal allantois morphology	J:76941
	abnormal head development	J:76941
	embryonic growth retardation	J:76941
	embryonic lethality during organogenesis, complete penetrance	J:76941

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