Hdac1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hdac1
histone deacetylase 1
MGI:108086

54 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac1^MommeD5/Hdac1^MommeD5 FVB/NJ-Hdac1^MommeD5	embryonic growth arrest	J:142335
	embryonic growth retardation	J:142335
	prenatal lethality, complete penetrance	J:142335
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129 * C57BL/6 * CBA	no abnormal phenotype detected	J:150709
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Tg(KRT14-cre)1Ipc/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal coat appearance	J:205733
	abnormal epidermal layer morphology	J:205733
	abnormal epidermis stratum basale morphology	J:205733
	abnormal eyelid morphology	J:205733
	abnormal hair follicle development	J:205733
	abnormal hair follicle morphology	J:205733
	abnormal hair follicle orientation	J:205733
	abnormal hair medulla	J:205733
	abnormal hair shaft morphology	J:205733
	abnormal keratinocyte differentiation	J:205733
	abnormal keratinocyte morphology	J:205733
	abnormal nail color	J:205733
	abnormal nail matrix morphology	J:205733
	abnormal nail morphology	J:205733
	abnormal periorbital region morphology	J:205733
	abnormal sebaceous gland morphology	J:205733
	abnormal tail morphology	J:205733
	abnormal vibrissa morphology	J:205733
	abnormal zigzag hair morphology	J:205733
	alopecia	J:205733
	decreased body size	J:205733
	dilated hair follicle infundibulum	J:205733
	distorted hair follicle pattern	J:205733
	ectopic melanocytes	J:205733
	epidermal hyperplasia	J:205733
	epithelioid cyst	J:205733
	hyperkeratosis	J:205733
	increased foot pad pigmentation	J:205733
	increased tail pigmentation	J:205733
	Meibomian gland hyperplasia	J:205733
	narrow eye opening	J:205733
	short hair	J:205733
	short vibrissae	J:205733
	thick epidermis	J:205733
	thin epidermis stratum granulosum	J:205733
Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Tg(Myh6-cre)2182Mds/? involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	no abnormal phenotype detected	J:123173
Hdac1^tm1.1Mrl/Hdac1^tm1.1Mrl Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	normal hematopoietic system phenotype	J:197818
	normal liver/biliary system phenotype	J:197818
Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased cell proliferation	J:157903
Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	normal immune system phenotype	J:194769
Hdac1^tm1.2Eno/Hdac1^tm1.2Eno involves: 129S/SvEv * C57BL/6 * CD-1	embryonic lethality, complete penetrance	J:123173
Hdac1^tm1.2Pmt/Hdac1^tm1.2Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal cell cycle	J:157903
	embryonic lethality, complete penetrance	J:157903
Hdac1^{tm1b(EUCOMM)Wtsi}/Hdac1⁺ C57BL/6N-Hdac1^{tm1b(EUCOMM)Wtsi}/Ieg	cardiovascular system phenotype	J:211773
	decreased exploration in new environment	J:211773
	decreased heart rate variability	J:211773
	decreased mean corpuscular hemoglobin	J:211773
Hdac1^{tm1b(EUCOMM)Wtsi}/Hdac1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Hdac1^{tm1b(EUCOMM)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Hdac1^tm1Sei/Hdac1⁺ either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	prenatal lethality, incomplete penetrance	J:76941
Hdac1^tm1Sei/Hdac1^tm1Sei either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal allantois morphology	J:76941
	abnormal head development	J:76941
	embryonic growth retardation	J:76941
	embryonic lethality during organogenesis, complete penetrance	J:76941

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24