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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hdac1
histone deacetylase 1
MGI:108086
60 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hdac1tm1.1Eno/Hdac1tm1.1Eno
Hdac2tm1.1Eno/Hdac2+
Tg(KRT14-cre)1Ipc/0
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal coat appearance J:205733
abnormal epidermal layer morphology J:205733
abnormal nail color J:205733
abnormal nail morphology J:205733
abnormal vibrissa morphology J:205733
hyperkeratosis J:205733
increased foot pad pigmentation J:205733
narrow eye opening J:205733
short vibrissae J:205733
Hdac1tm1.1Eno/Hdac1tm1.1Eno
Hdac2tm1.1Eno/Hdac2tm1.1Eno
Tg(Myh6-cre)2182Mds/?
involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N 		dilated heart ventricle J:123173
increased cardiomyocyte apoptosis J:123173
irregular heartbeat J:123173
postnatal lethality, incomplete penetrance J:123173
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal megakaryocyte morphology J:197818
anemia J:197818
decreased bone marrow cell number J:197818
decreased erythrocyte cell number J:197818
decreased megakaryocyte cell number J:197818
lethargy J:197818
thrombocytopenia J:197818
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal mitosis J:197818
decreased fibroblast proliferation J:197818
early cellular replicative senescence J:197818
Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		anemia J:197818
decreased bone marrow cell number J:197818
decreased erythrocyte cell number J:197818
decreased megakaryocyte cell number J:197818
increased apoptosis J:197818
internal hemorrhage J:197818
lethargy J:197818
premature death J:197818
thrombocytopenia J:197818
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal cell cycle J:157903
increased fibroblast apoptosis J:157903
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Cd79atm1(cre)Reth/Cd79a+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N 		abnormal spleen morphology J:157903
arrested B cell differentiation J:157903
decreased B cell number J:157903
decreased bone marrow cell number J:157903
decreased pre-B cell number J:157903
decreased pro-B cell number J:157903
increased B cell apoptosis J:157903
Hdac1tm1.1Pmt/Hdac1tm1.1Pmt
Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Tg(Fcer2a-cre)5Mbu/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N 		decreased B cell proliferation J:157903
increased B cell apoptosis J:157903
Hdac1tm1.1Shmc/Hdac1+
Hdac2tm1.1Shmc/Hdac2tm1.1Shmc
Tg(Lck-cre)1Cwi/0
involves: 129S7/SvEvBrd 		normal immune system phenotype J:194769
Hdac1tm1.1Shmc/Hdac1tm1.1Shmc
Hdac2tm1.1Shmc/Hdac2+
Tg(Lck-cre)1Cwi/0
involves: 129S7/SvEvBrd 		arrested T cell differentiation J:194769
decreased CD4-positive, alpha-beta T cell number J:194769
decreased CD8-positive, alpha-beta T cell number J:194769
decreased double-positive T cell number J:194769
distended abdomen J:194769
enlarged chest J:194769
enlarged spleen J:194769
enlarged thymus J:194769
increased double-negative T cell number J:194769
increased double-positive T cell number J:194769
increased pulmonary respiratory rate J:194769
increased single-positive T cell number J:194769
increased tumor incidence J:194769
premature death J:194769
thymus hypoplasia J:194769
Hdac1tm1.1Shmc/Hdac1tm1.1Shmc
Hdac2tm1.1Shmc/Hdac2tm1.1Shmc
Tg(Lck-cre)1Cwi/0
involves: 129S7/SvEvBrd 		abnormal thymus corticomedullary boundary morphology J:194769
aneuploidy J:194769
arrested T cell differentiation J:194769
chromosomal instability J:194769
decreased double-positive T cell number J:194769
decreased thymocyte number J:194769
distended abdomen J:194769
enlarged chest J:194769
enlarged spleen J:194769
enlarged thymus J:194769
increased double-positive T cell number J:194769
increased pulmonary respiratory rate J:194769
increased single-positive T cell number J:194769
increased T cell derived lymphoma incidence J:194769
increased T cell proliferation J:194769
increased thymocyte apoptosis J:194769
increased thymocyte number J:194769
increased tumor incidence J:194769
premature death J:194769
trisomy J:194769
Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae
involves: 129S4/SvJae * C57BL/6 		abnormal hippocampus pyramidal cell morphology J:148391
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory