Gab1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gab1
growth factor receptor bound protein 2-associated protein 1
MGI:108088

52 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gab1^tm1Ajw/Gab1^tm1Ajw involves: 129X1/SvJ * C57BL/6	abnormal cardiovascular system morphology	J:83953
	abnormal extraembryonic tissue morphology	J:83953
	lethality throughout fetal growth and development, complete penetrance	J:83953
Gab1^tm1Gsf/Gab1^tm1Gsf Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal glucose homeostasis	J:98318
	abnormal lipid homeostasis	J:98318
	decreased circulating free fatty acids level	J:98318
	decreased circulating glucose level	J:98318
	decreased circulating insulin level	J:98318
	decreased circulating triglyceride level	J:98318
	decreased glycogen level	J:98318
	improved glucose tolerance	J:98318
	increased insulin sensitivity	J:98318
Gab1^tm1Thir/Gab1^tm1Thir involves: C57BL/6	abnormal epidermis stratum granulosum morphology	J:61790
	abnormal hair follicle development	J:61790
	absent eyelids	J:61790
	decreased embryo size	J:61790
	decreased trophoblast giant cell number	J:61790
	dilated heart left ventricle	J:61790
	dilated heart right ventricle	J:61790
	early eyelid opening	J:61790
	hemopericardium	J:61790
	hemorrhage	J:61790
	lethality throughout fetal growth and development, complete penetrance	J:61790
	petechiae	J:61790
	placental labyrinth hypoplasia	J:61790
	small placenta	J:61790
	thin epidermis	J:61790
	thin ventricular wall	J:61790
	ventricular hypoplasia	J:61790
Gab1^tm1Wbm/Gab1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal behavior	J:68751
Gab1^tm1Wbm/Gab1⁺ involves: 129P2/OlaHsd * C57BL/6	postnatal lethality, incomplete penetrance	J:68751
Gab1^tm1Wbm/Gab1^tm1Wbm involves: 129P2/OlaHsd	abnormal intrinsic tongue muscle morphology	J:100909
	abnormal muscle precursor cell migration	J:100909
	hypaxial muscle hypoplasia	J:100909
Gab1^tm1Wbm/Gab1^tm1Wbm involves: 129P2/OlaHsd * C57BL/6	abnormal diaphragm development	J:68751
	abnormal hair follicle development	J:68751
	abnormal keratinocyte physiology	J:68751
	abnormal muscle precursor cell migration	J:68751
	abnormal placenta labyrinth morphology	J:68751
	abnormal placenta vasculature	J:68751
	decreased liver weight	J:68751
	decreased trophoblast giant cell number	J:68751
	disorganized placental labyrinth	J:68751
	fetal growth retardation	J:68751
	hypaxial muscle hypoplasia	J:68751
	lethality throughout fetal growth and development, complete penetrance	J:68751
	thin epidermis	J:68751
	thin placenta labyrinth	J:68751
Gab1^tm1Wbm/Gab1^tm1Wbm involves: 129P2/OlaHsd * C57BL/6 * CD-1	abnormal skeletal muscle morphology	J:125303
	cleft secondary palate	J:125303
	decreased skeletal muscle mass	J:125303
Gab1^tm2Wbm/Gab1^tm2Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	abnormal placenta labyrinth morphology	J:125303
	cleft secondary palate	J:125303
	decreased liver weight	J:125303
	lethality throughout fetal growth and development, complete penetrance	J:125303
	normal muscle phenotype	J:125303
	palatal shelves fail to meet at midline	J:125303
Gab1^tm2Wbm/Gab1^tm3Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	decreased liver weight	J:125303
	disorganized placental labyrinth	J:125303
	thin placenta labyrinth	J:125303
Gab1^tm3Wbm/Gab1^tm3Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	cleft secondary palate	J:125303
	decreased liver weight	J:125303
	disorganized placental labyrinth	J:125303
	lethality throughout fetal growth and development, complete penetrance	J:125303
	normal muscle phenotype	J:125303
	palatal shelves fail to meet at midline	J:125303
	thin placenta labyrinth	J:125303
Gab1^tm4Wbm/Gab1^tm4Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	eyelids open at birth	J:125303
	impaired wound healing	J:125303
Gab1^tm5Wbm/Gab1^tm5Wbm involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	abnormal cell migration	J:125303
	abnormal muscle precursor cell morphology	J:125303
	abnormal myogenesis	J:125303
	disorganized placental labyrinth	J:125303
	embryonic lethality during organogenesis, incomplete penetrance	J:125303
	thin placenta labyrinth	J:125303

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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