Ei24 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ei24
etoposide induced 2.4 mRNA
MGI:108090

42 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ei24^tm1.1Hzha/Ei24^tm1.1Hzha involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N	prenatal lethality, complete penetrance	J:193420
Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal hepatocyte mitochondrial morphology	J:193420
	abnormal hepatocyte morphology	J:193420
	abnormal liver lobule morphology	J:193420
	abnormal liver morphology	J:193420
	enlarged liver	J:193420
	impaired autophagy	J:193420
Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal axon morphology	J:193420
	abnormal behavior	J:193420
	abnormal brain white matter morphology	J:193420
	abnormal cerebellum fissure morphology	J:193420
	abnormal cerebral cortex morphology	J:193420
	abnormal hippocampus pyramidal cell layer	J:193420
	abnormal involuntary movement	J:193420
	abnormal motor capabilities/coordination/movement	J:193420
	abnormal nervous system morphology	J:193420
	abnormal oligodendrocyte morphology	J:193420
	abnormal Purkinje cell morphology	J:193420
	astrocytosis	J:193420
	ataxia	J:193420
	axon degeneration	J:193420
	axonal dystrophy	J:193420
	axonal spheroids	J:193420
	brain vacuoles	J:193420
	decreased body weight	J:193420
	decreased cerebral cortex pyramidal cell number	J:193420
	decreased hippocampus pyramidal cell number	J:193420
	decreased myelin sheath thickness	J:193420
	decreased neuron number	J:193420
	decreased Purkinje cell number	J:193420
	enlarged lateral ventricles	J:193420
	impaired autophagy	J:193420
	impaired coordination	J:193420
	increased neuron apoptosis	J:193420
	limb grasping	J:193420
	normal nervous system phenotype	J:196603
	neuronal cytoplasmic inclusions	J:193420
	postnatal growth retardation	J:193420
	premature death	J:193420
	reduced cerebellar foliation	J:193420
	thin cerebellar molecular layer	J:193420
	thin cerebral cortex	J:193420
	tremors	J:193420

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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