Prkg1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkg1
protein kinase, cGMP-dependent, type I
MGI:108174

55 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kit^{tm1(cre/ERT2)Dsa}/Kit⁺ Prkg1^tm2Naw/Prkg1^tm2Naw involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal gastrointestinal motility	J:204737
	abnormal intestinal peristalsis	J:204737
	abnormal intestinal transit time	J:204737
Myl7^tm1(cre)Krc/Myl7⁺ Prkg1^tm2Naw/Prkg1^tm2Naw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal cardiac muscle contractility	J:84611
Neurod6^tm1(cre)Kan/Neurod6⁺ Prkg1^tm2Naw/Prkg1^tm2.1Naw involves: 129S1/Sv * 129X1/SvJ	normal behavior/neurological phenotype	J:84444
	normal cardiovascular system phenotype	J:84444
	normal digestive/alimentary phenotype	J:84444
	normal mortality/aging	J:84444
	normal nervous system phenotype	J:84444
	reduced long-term potentiation	J:84444
Prkg1^tm1.1Pfe/Prkg1^tm1.1Pfe involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal adipose tissue development	J:199222
Prkg1^{tm1b(KOMP)Wtsi}/Prkg1⁺ C57BL/6N-Prkg1^{tm1b(KOMP)Wtsi}/H	enlarged heart	J:211773
	increased startle reflex	J:211773
Prkg1^{tm1b(KOMP)Wtsi}/Prkg1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkg1^{tm1b(KOMP)Wtsi}/H	abnormal duodenum morphology	J:211773
	enlarged spleen	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkg1^tm1Hfm/Prkg1^tm1Hfm involves: C57BL/6N	abnormal adipose tissue development	J:199222
	abnormal brown adipose tissue thermogenesis	J:199222
	decreased body surface temperature	J:199222
	decreased brown adipose tissue amount	J:199222
	decreased brown fat cell lipid droplet size	J:199222
	decreased fat cell mitochondrial DNA content	J:199222
	decreased triglyceride level	J:199222
Prkg1^tm1Hfm/Prkg1^tm1Hfm Not Specified	abnormal cardiac muscle relaxation	J:48058
	abnormal intestinal peristalsis	J:48058
	abnormal intestinal transit time	J:48058
	abnormal intestine morphology	J:48058
	abnormal penile erection	J:60928
	abnormal systemic arterial blood pressure	J:48058
	abnormal vascular smooth muscle physiology	J:48058
	hypertension	J:48058
	impaired muscle relaxation	J:48058, J:60928
	impaired smooth muscle contractility	J:94387
	increased mean systemic arterial blood pressure	J:48058
	pyloric sphincter hypertrophy	J:48058
	pyloric stenosis	J:48058
	reduced male fertility	J:60928
	stomach fundus hypertrophy	J:48058
Prkg1^tm1Meme/Prkg1^tm1Meme involves: 129S/SvEv	abnormal blood vessel physiology	J:134634
	decreased vasodilation	J:134634
	increased mean systemic arterial blood pressure	J:134634
	increased systemic arterial blood pressure	J:134634
	increased systemic arterial diastolic blood pressure	J:134634
	increased systemic arterial systolic blood pressure	J:134634
	normal renal/urinary system phenotype	J:134634
	salt-resistant hypertension	J:134634
Prkg1^tm1Naw/Prkg1^tm1Naw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal cardiac muscle contractility	J:84611
	premature death	J:84611
Prkg1^tm2.1Naw/Prkg1^tm2.1Naw involves: 129S1/Sv * 129X1/SvJ	abnormal circulating hormone level	J:134639
	abnormal erythrocyte morphology	J:134639
	abnormal intestinal transit time	J:134928
	abnormal vascular smooth muscle physiology	J:134928
	anemia	J:134639
	decreased erythrocyte cell number	J:134639
	decreased hematocrit	J:134639
	enlarged spleen	J:134639
	increased erythrocyte clearance	J:134639
	increased mean corpuscular hemoglobin	J:134639
	increased mean corpuscular volume	J:134639
	increased mean systemic arterial blood pressure	J:134928
	increased red blood cell distribution width	J:134639
	premature death	J:134928
	reticulocytosis	J:134639
Prkg1^tm2Naw/Prkg1^tm2Naw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	no abnormal phenotype detected	J:84611
Prkg1^tm2Naw/Prkg1^tm2Naw Tg(Pcp2-cre)2Mpin/? involves: 129/Sv * C57BL/6	abnormal long-term depression	J:86329

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