Alx4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Alx4
aristaless-like homeobox 4
MGI:108359

63 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alx1^em1Jian/Alx1^em1Jian Alx4^Lst-2J/Alx4⁺ involves: C57BL/6J * C57BL/6N * CD-1	abnormal lateral nasal prominence morphology	J:320497
	abnormal premaxilla morphology	J:320497
	abnormal presphenoid bone morphology	J:320497
	broad nasal bridge	J:320497
	depressed nasal bridge	J:320497
	midline cleft upper lip	J:320497
	short philtrum	J:320497
Alx1^em1Jian/Alx1^em1Jian Alx4^Lst-2J/Alx4^Lst-2J involves: C57BL/6J * C57BL/6N * CD-1	abnormal lateral nasal prominence morphology	J:320497
	abnormal medial nasal prominence morphology	J:320497
	abnormal premaxilla morphology	J:320497
	midline cleft upper lip	J:320497
	midline facial cleft	J:320497
Alx1^tm1Crm/Alx1⁺ Alx4^tm1Rwi/Alx4⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd	no abnormal phenotype detected	J:51128
Alx1^tm1Crm/Alx1⁺ Alx4^tm1Rwi/Alx4^tm1Rwi involves: 129S6/SvEvTac * 129S7/SvEvBrd	abnormal basisphenoid bone morphology	J:51128
	abnormal nasal septum cartilage morphology	J:51128
	abnormal neurocranium morphology	J:51128
	cleft palate	J:51128
	eyelids open at birth	J:51128
	herniated abdominal wall	J:51128
	midline facial cleft	J:51128
	polydactyly	J:51128
	short mandible	J:51128
	short tibia	J:51128
	small frontal bone	J:51128
	small mandible	J:51128
	small occipital bone	J:51128
	small parietal bone	J:51128
	small temporal bone	J:51128
Alx1^tm1Crm/Alx1^tm1Crm Alx4^lst-J/Alx4^lst-J involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J	abnormal clavicle morphology	J:101708
	abnormal scapula morphology	J:101708
	abnormal scapular spine morphology	J:101708
	small acromion	J:101708
	small pubis	J:101708
Alx1^tm1Crm/Alx1^tm1Crm Alx4^lst-J/Alx4^lst-J Tbx15^de-H/Tbx15⁺ involves: 129S7/SvEvBrd * C3H * C57BL/6J	abnormal scapula morphology	J:101708
	abnormal scapular spine morphology	J:101708
Alx1^tm1Crm/Alx1^tm1Crm Alx4^lst-J/Alx4^lst-J Tbx15^de-H/Tbx15^de-H involves: 129S7/SvEvBrd * C3H * C57BL/6J	absent clavicle	J:101708
	small scapula	J:101708
Alx1^tm1Crm/Alx1^tm1Crm Alx4^tm1Rwi/Alx4⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd	abnormal basisphenoid bone morphology	J:51128
	abnormal nasal septum cartilage morphology	J:51128
	exencephaly	J:51128
	midline facial cleft	J:51128
	short mandible	J:51128
Alx1^tm1Crm/Alx1^tm1Crm Alx4^tm1Rwi/Alx4^tm1Rwi involves: 129S6/SvEvTac * 129S7/SvEvBrd	asymmetric rib joints	J:51128
	decreased rib number	J:51128
	exencephaly	J:51128
	herniated abdominal wall	J:51128
	midline facial cleft	J:51128
	polydactyly	J:51128
	short tibia	J:51128
	split sternum	J:51128
Alx3^tm1Hubr/Alx3^tm1Hubr Alx4^lst-J/Alx4^lst-J involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N	abnormal basicranium morphology	J:71880
	abnormal clavicle morphology	J:71880
	abnormal craniofacial bone morphology	J:71880
	abnormal cranium morphology	J:71880
	abnormal mandible morphology	J:71880
	abnormal maxilla morphology	J:71880
	abnormal maxillary frontal process morphology	J:71880
	abnormal nasal capsule morphology	J:71880
	abnormal nasal cavity morphology	J:71880
	abnormal neurocranium morphology	J:71880
	abnormal premaxilla morphology	J:71880
	abnormal pterygoid process morphology	J:71880
	abnormal viscerocranium morphology	J:71880
	absent deltoid tuberosity	J:71880
	absent facial bone	J:71880
	absent gastric milk in neonates	J:71880
	absent nasal septum	J:71880
	bifid nasal tip	J:71880
	bifid nose	J:71880
	cleft palate	J:71880
	decreased cranium height	J:71880
	exophthalmos	J:71880
	eyelids open at birth	J:71880
	increased cranium width	J:71880
	large fontanelles	J:71880
	meteorism	J:71880
	midline facial cleft	J:71880
	neonatal lethality, complete penetrance	J:71880
	preaxial polydactyly	J:71880
	short facial bone	J:71880
	short temporal bone squamous part	J:71880
	small alisphenoid bone	J:71880
	small frontal bone	J:71880
	small nasal bone	J:71880
	small parietal bone	J:71880
Alx3^tm1Hubr/Alx3^tm1Hubr Alx4^lst-J/Alx4^lst-J involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	small pubis	J:101708
Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺ Not Specified	normal limbs/digits/tail phenotype	J:35172
Alx4^lst/Alx4⁺ Grem1^ld-J/Grem1⁺ involves: CBA/Ca * NHO	normal limbs/digits/tail phenotype	J:35172
Alx4^lst/Alx4⁺ Fmn1^ld-TgHD/Fmn1⁺ involves: BALB/c * C57BL/6 * CD-1 * FVB/N	normal limbs/digits/tail phenotype	J:17401
Alx4^tm1Rwi/Alx4⁺ Bmp4^tm1Blh/Bmp4⁺ involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	polydactyly	J:42445

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24