Rgs4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rgs4
regulator of G-protein signaling 4
MGI:108409

26 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rgs4^em1(IMPC)H/Rgs4^em1(IMPC)H C57BL/6N-Rgs4^em1(IMPC)H/H	decreased lymphocyte cell number	J:211773
	increased eosinophil cell number	J:211773
	increased mean corpuscular volume	J:211773
	increased spleen weight	J:211773
Rgs4^tm1.1Amus/Rgs4^tm1.1Amus B6.129-Rgs4^tm1.1Amus	decreased renal plasma flow rate	J:195186
Rgs4^tm1.1Amus/Rgs4^tm1.1Amus B6.129-Rgs4^tm1.1Amus	increased susceptibility to xenobiotic induced morbidity/mortality	J:195186
Rgs4^tm1.1Jbr/Rgs4^tm1.1Jbr involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal touch/ nociception	J:98888
	decreased behavioral withdrawal response	J:98888
	decreased body weight	J:98888
	embryonic lethality between somite formation and embryo turning, incomplete penetrance	J:98888
	impaired behavioral response to morphine	J:98888
	impaired coordination	J:98888
	normal nervous system phenotype	J:98888
Rgs4^tm1.1Jlr/Rgs4^tm1.1Jlr involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac	no abnormal phenotype detected	J:160728
Rgs4^tm1Dgen/Rgs4^tm1Dgen B6.129P2-Rgs4^tm1Dgen	normal behavior/neurological phenotype	J:171292
	decreased aggression towards mice	J:171292
	hyperactivity	J:171292
	impaired conditioned place preference behavior	J:171292
	increased vertical activity	J:171292
Rgs4^tm1Dgen/Rgs4^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	increased circulating cholesterol level	J:101679
	increased circulating HDL cholesterol level	J:101679
	increased total body fat amount	J:101679
Rgs4^tm1Sdlk/Rgs4^tm1Sdlk Tg(Myh11-icre/ERT2)1Soff/? involves: FVB/N	abnormal macrophage chemotaxis	J:215588
	abnormal renal tubule morphology	J:215588
	increased circulating creatinine level	J:215588
	increased susceptibility to induced morbidity/mortality	J:215588

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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