About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfe2l2
nuclear factor, erythroid derived 2, like 2
MGI:108420
142 phenotypes from 6 alleles in 14 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Nfe2l2em1(IMPC)Ccpcz/Nfe2l2em1(IMPC)Ccpcz
C57BL/6NCrl-Nfe2l2em1(IMPC)Ccpcz/Ccpcz 		abnormal lymph node morphology J:211773
abnormal ovary morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal skin morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
abnormal tooth morphology J:211773
decreased body weight J:211773
decreased circulating glucose level J:211773
enlarged lymph nodes J:211773
enlarged seminal vesicle J:211773
enlarged thymus J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating bilirubin level J:211773
increased circulating creatinine level J:211773
increased circulating lactate dehydrogenase level J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular hemoglobin concentration J:211773
increased mean platelet volume J:211773
small testis J:211773
Nfe2l2tm1.1Sred/Nfe2l2tm1.1Sred
Tg(Scgb1a1-cre)1Grau/0
involves: C57BL/6 * C57BL/6J 		abnormal cell death J:191916
decreased interleukin-1 beta secretion J:191916
decreased tumor necrosis factor secretion J:191916
increased susceptibility to injury J:191916
Nfe2l2tm1Mym/Nfe2l2+
involves: 129P2/OlaHsd 		abnormal enamel morphology J:95372
abnormal iron level J:95372
Nfe2l2tm1Mym/Nfe2l2tm1Mym
B6.129P2-Nfe2l2tm1Mym 		decreased body weight J:208590
normal homeostasis/metabolism phenotype J:208590
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd 		abnormal enamel morphology J:95372
abnormal incisor color J:95372
abnormal iron homeostasis J:95372
abnormal iron level J:95372
abnormal tooth morphology J:95372
ameloblast degeneration J:95372
increased liver iron level J:95372
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * C57BL/6 		abnormal leukocyte adhesion J:150597
abnormal physiological response to xenobiotic J:136120
cachexia J:136120
hypoglycemia J:136120
increased circulating alanine transaminase level J:136120
increased circulating interleukin-6 level J:136120
increased circulating tumor necrosis factor level J:136120
increased hepatocyte apoptosis J:136120
increased susceptibility to experimental autoimmune uveoretinitis J:150597
increased susceptibility to xenobiotic induced morbidity/mortality J:136120
liver inflammation J:136120
macrovesicular hepatic steatosis J:136120
oxidative stress J:150597
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * C57BL/6J 		increased susceptibility to induced colitis J:116676
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * CD-1 		abnormal behavior J:122813
circling J:122813
increased acute inflammation J:122813
increased cerebral infarct size J:122813
increased susceptibility to ischemic brain injury J:122813
Nfe2l2tm1Mym/Nfe2l2tm1Mym
involves: 129P2/OlaHsd * ICR 		abnormal glomerular capillary morphology J:104016
abnormal glomerular mesangium morphology J:104016
abnormal macrophage physiology J:118068
abnormal physiological response to xenobiotic J:68072, J:118068
abnormal renal glomerulus morphology J:104016
abnormal respiratory system physiology J:118068
decreased CD4-positive, alpha-beta T cell number J:104016
decreased T cell number J:104016
decreased urine creatinine level J:104016
enlarged lymph nodes J:104016
glomerular crescent J:104016
glomerulonephritis J:104016
glomerulosclerosis J:104016
normal hematopoietic system phenotype J:41943
increased anti-double stranded DNA antibody level J:104016
increased anti-nuclear antigen antibody level J:104016
increased IgG level J:104016
increased IgM level J:104016
increased incidence of tumors by chemical induction J:68072
increased kidney cell proliferation J:104016
increased lung weight J:118068
increased mesangial cell number J:104016
increased spleen weight J:104016
increased stomach tumor incidence J:68072
increased urine protein level J:104016
lung inflammation J:118068
oxidative stress J:104016
premature death J:104016
pulmonary fibrosis J:118068
weight loss J:118068
Nfe2l2tm1Ney/Nfe2l2tm1Ney
involves: 129X1/SvJ * C57BL/6 		normal hematopoietic system phenotype J:47440
Nfe2l2tm1Sud/Nfe2l2tm1Sud
involves: 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:101977
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
B6.129X1-Nfe2l2tm1Ywk 		abnormal enzyme/coenzyme activity J:165602
abnormal enzyme/coenzyme level J:165602, J:310044
abnormal lipid homeostasis J:165602
abnormal male germ cell morphology J:165602
abnormal ovary physiology J:310044
abnormal seminiferous tubule morphology J:165602
abnormal spermatogenesis J:165602
asthenozoospermia J:165602
normal behavior/neurological phenotype J:165602
normal cellular phenotype J:310044
decreased epididymis weight J:165602
decreased glutathione level J:165602, J:310044
decreased glutathione peroxidase activity J:165602
decreased primordial ovarian follicle number J:310044
decreased tertiary ovarian follicle number J:310044
decreased testis weight J:165602
early reproductive senescence J:310044
normal homeostasis/metabolism phenotype J:165602, J:310044
increased anti-double stranded DNA antibody level J:165602
increased male germ cell apoptosis J:165602
normal limbs/digits/tail phenotype J:165602
normal mortality/aging J:165602
oligozoospermia J:165602
oxidative stress J:165602
polyovular ovarian follicle J:310044
reduced male fertility J:165602
normal renal/urinary system phenotype J:165602
seminiferous tubule degeneration J:165602
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
B6.129X1-Nfe2l2tm1Ywk/J 		abnormal neutrophil physiology J:233699
abnormal periodontal ligament morphology J:233699
alveolar process atrophy J:233699
decreased catalase level J:233699
oxidative stress J:233699
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
involves: 129X1/SvJ 		abnormal erythrocyte physiology J:91407
abnormal liver physiology J:130473
abnormal myelin sheath morphology J:122195
abnormal spleen physiology J:91407
abnormal splenocyte physiology J:91407
abnormal tooth color J:91407
acanthocytosis J:91407
anisocytosis J:91407
astrocytosis J:122195
decreased circulating interleukin-1 beta level J:100106
decreased erythrocyte cell number J:91407
decreased hematocrit J:91407
decreased hemoglobin content J:91407
decreased hepatocyte proliferation J:130473
decreased liver weight J:130473
delayed liver regeneration J:130473
normal embryo phenotype J:37053
enlarged spleen J:91407
normal hematopoietic system phenotype J:37053
hemolytic anemia J:91407
normal homeostasis/metabolism phenotype J:100106
increased cellular sensitivity to hydrogen peroxide J:91407
increased circulating bilirubin level J:130473
increased circulating interleukin-1 beta level J:100106
increased fibroblast apoptosis J:86725
increased lactate dehydrogenase level J:91407
increased macrophage cell number J:100106
increased number of Howell-Jolly bodies J:91407
increased spleen weight J:91407
increased splenocyte apoptosis J:91407
oxidative stress J:86725, J:91407, J:122195, J:130473
poikilocytosis J:91407
reticulocytosis J:91407
schistocytosis J:91407
spongiform encephalopathy J:122195
thrombocytopenia J:91407
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
involves: 129X1/SvJ * C57BL 		enlarged lung J:112943
increased physiological sensitivity to xenobiotic J:112943
increased susceptibility to xenobiotic induced morbidity/mortality J:112943
lung hemorrhage J:112943
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory