Nfe2l2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfe2l2
nuclear factor, erythroid derived 2, like 2
MGI:108420

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ahr^tm1Yfk/Ahr^tm1Yfk Nfe2l2^tm1Mym/Nfe2l2^tm1Mym involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR	abnormal xenobiotic pharmacokinetics	J:82937
	decreased survivor rate	J:82937
	hepatic steatosis	J:82937
	postnatal lethality, incomplete penetrance	J:82937
Apoe^tm1Unc/Apoe^tm1Unc Nfe2l2^tm1Mym/Nfe2l2^tm1Mym involves: 129P2/OlaHsd * C57BL/6J	abnormal aorta morphology	J:143903
	abnormal macrophage physiology	J:143903
	decreased susceptibility to atherosclerosis	J:143903
	increased circulating glucose level	J:143903
	increased circulating triglyceride level	J:143903
	oxidative stress	J:143903
Keap1^tm1Mym/Keap1^tm1Mym Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Not Specified	normal digestive/alimentary phenotype	J:86392
	normal integument phenotype	J:86392
Lep^ob/Lep^ob Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi Tg(Fabp4-cre)1Rev/0 involves: C57BL/6	abnormal white fat cell morphology	J:208590
	decreased white adipose tissue amount	J:208590
	normal homeostasis/metabolism phenotype	J:208590
	increased circulating glucose level	J:208590
	increased circulating triglyceride level	J:208590
	insulin resistance	J:208590
Lep^ob/Lep^ob Nfe2l2^tm1Mym/Nfe2l2^tm1Mym B6.Cg-Nfe2l2^tm1Mym Lep^ob	abnormal adipose tissue development	J:208590
	abnormal urine color	J:208590
	abnormal white fat cell morphology	J:208590
	decreased body weight	J:208590
	decreased food intake	J:208590
	decreased liver triglyceride level	J:208590
	decreased susceptibility to weight gain	J:208590
	decreased white adipose tissue amount	J:208590
	hepatic steatosis	J:208590
	normal homeostasis/metabolism phenotype	J:208590
	hyperglycemia	J:208590
	increased circulating triglyceride level	J:208590
	insulin resistance	J:208590
	premature death	J:208590
Nfe2^tm1Sho/Nfe2^tm1Sho Nfe2l2^tm1Ney/Nfe2l2^tm1Ney involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	anemia	J:47440
	thrombocytopenia	J:47440
Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk involves: 129X1/SvJ	decreased embryo size	J:86725
	embryonic growth retardation	J:86725
	embryonic lethality during organogenesis, complete penetrance	J:86725
	increased apoptosis	J:86725
	increased cellular sensitivity to oxidative stress	J:86725
	increased fibroblast apoptosis	J:86725
	oxidative stress	J:86725
Nfe2l2^tm1Mym/Nfe2l2^tm1Mym n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA/2	increased apoptosis	J:130723
	increased cellular sensitivity to hydrogen peroxide	J:130723
	increased cellular sensitivity to oxidative stress	J:130723
Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Tg(Alb1-cre)1Dlr/0 n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	abnormal hepatocyte morphology	J:130723
	increased circulating alanine transaminase level	J:130723
	increased hepatocyte apoptosis	J:130723
	lethality at weaning, incomplete penetrance	J:130723
	liver degeneration	J:130723
	pale liver	J:130723
	premature death	J:130723
Nfe2l2^tm1Ney/Nfe2l2^tm1Ney Nfe2l3^tm1Vbl/Nfe2l3^tm1Vbl involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:89893
Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Slc3a1^tm1Jat/Slc3a1^tm1Jat involves: 129 * 129X1/SvJ * C57BL/6	cystolithiasis	J:254803

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